摘要
目的:探讨低氮低热量短期肠外营养支持对恶性梗阻性黄疸患者减黄术后机体代谢功能和免疫功能的影响。方法:回顾性将90例恶性梗阻性黄疸患者,分为单纯肠外营养(A组30例)、肠外营养+复合性药物(B组30例)和对照组(C组30例)。采用不同方法解除胆道梗阻后,A组和B组给予低氮低热量肠外营养代谢支持,C组采用普通支持治疗。结果:全部患者均能耐受肠外营养支持,转氨酶、胆红素和胆汁酸指标下降,营养指标好转,血脂代谢改善,体液免疫和细胞免疫指标提高,P<0.05,B组较为明显。结论:胆道梗阻解除后,短期低氮低热量肠外营养是一种安全的临床营养支持过渡方法,对代谢功能和免疫功能具有明显的正相相关性,适当的复合性药物具有良好的代谢调理作用和免疫增强作用。
OBJECTIVE：To explore the effect of metabolic function and immune function of short-term periopreative hyponitrogenic and hypocaloric parenteral nutrition of patients with malignant obstructive jaundice.METHODS：Retrospective study 90 patients with malignant obstructive jaundice patients who accepted different treatment methods to relieve obstructive jaundice.All patients were divided into 3 groups（n=30）,a simple PN（A group）,PN＋multiple drugs（B group） and control group（C group）,respectively.Different treatment methods to relieve obstructive jaundice,following hyponitrogenic and hypocaloric parenteral nutrition support.To observe the changes of liver function,blood lipid,nutritional index and humoral immunity,cellular immunity.RESULTS：All patients after treatment were able to tolerate parenteral nutrition support,and nutritional index of patients were improved;the levels of liver enzyme,bilirubin and bile acid were decreased;humoral and cellular immunity indicators were improved,blood lipid metabolism tend to normal,and B group were obviously（P0.05）.CONCLUSIONS：Parenteral nutrition is safe after to relieve jaundice treatment for the patients with malignant obstructive jaundice.Parenteral nutrition can effectively improve the nutritional status of patients on the metabolic functions and immune function associated with a significantly positive correlation,the appropriate multiple drugs have good metabolic conditioning effect and immune enhancement.
出处
《中华肿瘤防治杂志》
CAS
2010年第21期1774-1777,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
氮/代谢
手术后期间
肠外营养
代谢功能
免疫功能
nitrogen/metabolism
postoperative period
parenteral nutrition
metabolic function
immune function
