摘要
目的探讨一氧化氮合酶抑制剂左旋硝基精氨酸甲酯（Ｌ－ＮＡＭＥ）对短暂性前脑缺血再灌注损伤中的作用。方法钳夹沙土鼠的双侧颈总动脉制造脑缺血模型，应用尼氏染色观察迟发性神经元坏死的分布与数量。结果短暂性前脑缺血再灌注可导致海马ＣＡ１区锥体细胞迟发性神经元坏死，一氧化氮合酶抑制剂Ｌ－ＮＡＭＥ明显地减少了迟发性神经元坏死。结论Ｌ－ＮＡＭＥ可能通过抑制神经原生型ＮＯＳ对脑缺血起保护作用。
Objective:To observe the role of nitric oxide synthase inhibitor(LNAME) in the cerebral ischemia reperfusional injury..Method:The distribution and number of death neurons were observed by Nissl's staining method on the animal models with ischemia obtained by bilateral occlusion of common carotid arteries.Results:The recirculation following ischemia could induce delayed neuronal death.L-NAME reduced DNA.Conclusion:It is possible that L-NAME protects brain after ischemia by inhibiting endogenous NOS.
出处
《泰山医学院学报》
CAS
1999年第2期121-122,共2页
Journal of Taishan Medical College
基金
山东省自然科学基金
