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婴幼儿体外循环后血糖变化的初步研究 被引量:2

Infants Blood Glucose Changes after Cardiopulmonary Bypass
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摘要 目的初步分析婴幼儿在体外循环术后血糖水平的变化规律及其影响因素。方法选择行心内直视手术患儿60例,按年龄、体重、体外循环时间分组。分为幼儿组(1~3岁)、婴儿组(≤1岁),体重≤10kg(A组)、体重〉10kg组(B组),体外循环时间〈60min(C组)、体外循环时间≥60min(D组)。观察患儿手术前(t0),手术结束时(t1),手术结束后1h(t2)、3h(t3)、5h(t4)血糖变化。结果体外循环术后各组血糖水平较转流前均明显升高;婴儿组与幼儿组相比手术结束时和术后1h血糖水平升高更明显;A组手术结束时和术后1、3h的血糖水平明显高于B组同时点血糖水平;D组手术结束和术后1h血糖水平明显高于C组同时点血糖水平。结论体外循环对小儿糖代谢有明显影响,体外循环期间糖代谢紊乱,血糖明显升高,且体外循环术对低龄、低体重、体外循环时间长的患儿血糖水平影响更大。 Objective To investigate the changes of plasma glucose in infants undergoing open cardiac surgery during and after cardiopulmonary bypass(CPB).Methods 60 cases' blood samples were taken at five different time points,before the operation(t0),at the end of operation(t1),1h after the operation(t2),3h after the operation(t3),and 5h after the operation(t4).60 cases were divided into groups by age.Body weight and CPB time: the baby group(≤one-year-old) and the little children group(one-year-old to three-year-old),the weight ≤10kg group(Group A) and the weight10kg group(Group B),the CPB time60min group(Group C) and the CPB time≥60min group(Group D).Results All groups' plasma glucose level significantly increased after the CPB.The plasma glucose level at t1 and t2 in baby group were significantly higher than that in little children group.The plasma glucose level at t2 and t3 in Group A were significantly higher than that in Group B.The plasma glucose level at t1 and t2 in Group D were significantly higher than that in Group C.Conclusion The cardiopulmonary bypass has obvious influence on the glucose metabolism in children.The glucose metabolism disorders in cardiopulmonary bypass can make the plasma glucose level increase obviously,and with the CPB time continue,the plasma glucose get higher level.In infants and low weight,the cardiopulmonary bypass has more obvious influence on the glucose,and The younger and lighter infants have the greater fluctuations in blood glucose at all time points.
出处 《宁夏医科大学学报》 2011年第3期246-248,共3页 Journal of Ningxia Medical University
关键词 体外循环 血糖 婴幼儿 心内直视手术 cardiopulmonary bypass blood glucose infant open-heart surgery
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  • 1武欣生,夏建海,谷兴琳.复方乳酸钠山梨醇液减轻小儿先心病矫治术中高血糖的临床观察[J].临床麻醉学杂志,2000,16(2):108-108. 被引量:5
  • 2段大为,杨景学,等.婴幼儿体外循环的特殊性[J].中华胸心血管外科杂志,2001,17(3):185-187. 被引量:62
  • 3Kaul A, Ramarao P. Sympathetic nervous system and experimental diabetes:role of adrenal medullary hormones [ J ]. Prog Drug Res ,2001,57 : 163.
  • 4DiNardo MM, Korytkowski MT, Siminerio IS. The importance of normoglycemia in criticall ill patients [ J ]. Crit care Nuts,2004,27 : 126 - 134.
  • 5Pulsinelli WA, Waldman S, Rawlinson D, et al. Moderate hyPerglyeemia augments isehemic brain damage:a neu- ropathological study in the Rat [ J ]. Neurology (NY) 2002,32 : 1239 - 1240.
  • 6Frdede R, VanHouten W. Relations between postmorten alterations and glyeolytic metabolism in the brain [ J ]. Exp Neuro1,2001,4 : 197 - 198.
  • 7Doenst T, Wijeysundera D, Karkouti K, et al. Hypergly- cemiaduring cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery [ J ]. J Thorac Cardiovasc Surg, 2005, 130 (4) :1144.

二级参考文献5

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同被引文献28

  • 1赵举,龙村,冯正义,杨九光,梁凤玲.库血预充液零平衡超滤对婴幼儿体外循环中炎性反应的影响[J].中国胸心血管外科临床杂志,2005,12(6):396-398. 被引量:6
  • 2孟凡浩,张凤英.体外循环前并行阶段心室颤动的原因及对策[J].中国体外循环杂志,2006,4(3):165-166. 被引量:3
  • 3李景文,龙村,袁泉,高国栋.婴幼儿围心脏手术期血乳酸浓度的变化与预后[J].中国体外循环杂志,2007,5(1):1-3. 被引量:26
  • 4陈文思,王潭枫,林美玲.ACD—B红细胞悬液保存期内生化指标的动态观察[J].国际医药卫生导报,2007,13(8):82-86. 被引量:2
  • 5Schroeder TH, Hansen M. Effects of fresh versus old stored blood in the priming solution on whole blood lactate levels during paediatric cardiac surgery. Perfusion, 2005, 20 ( 1 ) : 17-19.
  • 6Keidan I, Amir G, Mandel M, et al. The metabolic effects of fresh versus old stored blood in the priming of cardiopulmonary bypass solution for pediatric patients. J Thomc Cardiovasc Surg, 2004, 127 (4) : 949-952.
  • 7DiNardo MM, Korytkowski MT, Siminerio LS. The importance of normoglycemia in critically ill patients. Crit Care Nuts, 2004, 27 (2): 126-134.
  • 8Doenst T, Wijeysundem D, Karkouti K, et al. Hyperglycemia during cardiopulmonary bypass is an Independent risk factor for mortality in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg, 2005, 130(4): 1144.
  • 9de Vroege R, Wildevuur WR, Muradin JA, et al. Washing of stored red blood cells by an autotransfusion device before transfusion. Vox Sang, 2007, 92(2): 130-135.
  • 10Kirklin JW,Brian G,Barratt-Boyes.Cardiac surgery[M].2nd Ed.New York:Churchlli Livingstone,1993:1405-1410,773-779,749-824,885-915.

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