摘要
目的分析有高血压家族史但血压正常的青少年肱动脉内皮功能和血管活性物质的变化。方法对30例有高血压家族史、本人血压正常的青少年(家族史阳性组)和30例无高血压家族史、血压正常青少年(对照组),以高分辨率超声测定肱动脉血流介导内皮依赖性舒张功能(FMD),测量身高、体重、体质指数(BMI)、血压、血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和一氧化氮(NO)、血浆内皮素(ET-1)。结果与健康对照组相比,家族史阳性但血压正常的青少年的FMD和NO降低(P<0.05),ET-1虽升高但两组差异无统计学意义。结论有高血压家族史的青少年即使在血压正常时,已发生内皮依赖性舒张功能降低、血清NO水平下降。
Objective To observe the status of braehial artery endothelial function and changes of vasoactive substances in normotensive adolescents with family history of hypertension. Methods Normotensive 30 adolescents with hypertension family history （positive group）and 30 adolescents without hypertension family history （control group）were selected. Endothelium- dependent flow-mediated dilation （FMD）was assessed on the braehial artery using high-resolution ultrasound. Height, weight, body mass index （BMI）, blood pressure and plasma levels of total cholesterol （TC）, triglyeeride （TG）and low density lipoprotein （LDL-C）were detected. The plasma levels of nitric oxide（NO）and serum endothelial-I（ET-1 ）were also determined. Results The FMD and the serum NO in normotensive adoleseents with family history of hypertension was decreased significantly than that in normal control subjects （P〈0.05）. But there were no significant differences of the increased serum ET-I level in two groups. Conclusion Impairment of brachial artery endothelial function and reduction of serum NO level appears in normotensive adolescents with family history of hypertension.
出处
《中国慢性病预防与控制》
CAS
北大核心
2011年第2期168-169,共2页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
高血压
肱动脉
内皮依赖性舒张功能
一氧化氮
内皮素
Hypertension
Braehial artery
Endothelium-dependent diastole function
Nitric oxide
Endothelial-I
