摘要
目的:探讨红光照射对难治性创面的创缘组织中血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)的表达及治疗难治性创面的临床效果。方法:收集2008年6月-2010年12月因难治性创面入住笔者单位治疗的40例患者,按治疗方法分为红光照射治疗组20例和常规治疗组20例。常规治疗组患者创面以0.5%碘伏与水胶体敷料换药。治疗组在常规治疗的基础上加用红光照射。于治疗后第7天、14天、21天切取创缘组织,研究红光照射对创缘组织中VEGF的影响,并比较两组患者的创面愈合率和愈合时间。结果:临床实验中,治疗组创缘组织中的VEGF含量明显高于对照组(P<0.01);治疗组创面愈合率明显高于对照组(P<0.01);治疗组的愈合时间低于对照组(P<0.05)。结论:红光照射能显著提高创缘组织中VEGF含量,减少创面愈合时间,促进愈合。
Objective:To study the effect of red LED irradiation on the vascular endothelial growth factor(VEGF) expression in wounded tissue and its clinical effects.Methods:Immunohistochemical staining was used to detect the expression of VEGF in the wounded tissue in different time,the rate of wound surface healing and time of wound healing were also observed.Results:VEGF was expressed in the process of wound healing.The expression of VEGF in red LED irradiation group was higher than that in the control group.Conclusion:red LED irradiation could increase the expression of VEGF in the wounded tissue and promote wound healing.
出处
《现代生物医学进展》
CAS
2011年第7期1346-1348,共3页
Progress in Modern Biomedicine