摘要
目的探讨核因子-κB(NF-κB)和基质金属蛋白酶9(MMP-9)在胰腺癌侵袭转移中的表达。方法应用免疫组织化学法检测60例胰腺癌、26例正常胰腺组织中NF-κB和MMP-9的表达情况。结果 NF-κB和MMP-9在胰腺癌组织中表达阳性率分别为71.7%和63.3%,明显高于癌旁正常胰腺组织(P<0.01);NF-κB和MMP-9的表达与胰腺癌浸润转移均呈正相关(P<0.05);胰腺癌组织中NF-κB和MMP-9的表达呈正相关(P<0.05)。结论 NF-κB可能通过上调MMP-9的表达来促进胰腺癌的浸润、转移。检测两者表达有助于胰腺癌浸润转移的判断。
Objective To investigate the expressions and significance of neuclear factor（NF）-κB and matrix metalloproteinases-9（MMP-9） in pancreatic cancer.Methods The expressions of NF-κB and MMP-9 were detected by immunohistochemical method in 60 cases of pancreatic carcinoma（group A） and 26 tumor-adjacent normal pancreatic tissues（group B）.Results The expressions of the NF-κB and MMP-9 were remarkably higher in group A than those in group B（P0.01）.The expressions of NF-κB and MMP-9 were positively correlated to the invasion and metastasis of pancreatic carcinoma（P0.05）.The expression of NF-κB was positively correlated to that of MMP-9 in pancreatic carcinoma（P0.05）.Conclusion NF-κB may promote the invasion and metastasis of pancreatic carcinoma through upregulating the expression of MMP-9.The detection of NF-κB and MMP-9 expressions is helpful in evaluating the invasion and metastasis of pancreatic carcinoma.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第5期538-540,共3页
Jiangsu Medical Journal
基金
河南省教育厅自然科学研究项目(2008A31001)
关键词
核因子-ΚB
基质金属蛋白酶9
胰腺癌
Neuclear factor kappa B
Matrix metalloproteinases-9
Pancreatic carcinoma
