摘要
目的:探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)和尿β2-微球蛋白(β2-m)联检在2型糖尿病肾病(DM2-N)中的应用价值。方法:将105例DM2-N患者按尿白蛋白排泄率(UAER)分为A、B、C三组,A组:UAER〈20μg/min,45例;B组UAER 20~200μg/min,37例;C组UAER〉200μg/min,23例。用Olympus AU2700全自动生化分析仪检测血清Hcy、hs-CRP;尿β2-m采用E170型罗氏化学发光免疫分析仪检测。结果:各组DM2-N患者血清Hcy、hs-CRP和尿β2-m水平均明显升高,与对照组比较,有显著性差异(P〈0.05或P〈0.01)。结论:血清Hcy、hs-CRP和尿β2-m联检在协助临床做好DM2-N早预防、早发现、早治疗方面有其积极意义。
Objective To study the clinical value of combined measurement of serum Hcy,hs-CRP and urinary β2-m in patients with type 2 diabetic nephropathy.Methods 105 type 2 diabetic nephropathy patients were divided in to three groups according to their urine albumin excretion rate(UAER): Group A,UAER20μg/min(n=45),Group B,UAER 20~200μg/min(n=37),Group C,UAER200μg/min(n=23).Results Each group of type 2 diabetic nephropathy patients,the levels of serum homocystein,ultra sensitive C-reactive protein and urine β2-microglobulin were elevated obviously equally,compares with the control group,has the significant difference(P0.05 or P0.01).Conclusion The homocystein,high sensitive C-reactive protein and urine β2-microglobulin combined examination clinically makes type 2 diabetic nephropathy at the assistance to prevent,to discover,treats the aspect to have its positive sense early.
出处
《放射免疫学杂志》
CAS
2011年第2期209-211,共3页
Journal of Radioimmanology
关键词
同型半胱氨酸
超敏C反应蛋白
Β2-微球蛋白
糖尿病肾病
homocysteine(Hcy)
high-sensititvity C-reactive protein(hs-CRP)
β2-microglobulin(β2-m)
diabetic nephropathy(DN)