摘要
采用乙酸酐对琼脂糖进行疏水性改性,合成了具有生物活性的琼脂糖醋酸酯。通过红外光谱(FT-IR)、13C核磁共振(13C-NMR)、原子力显微镜和接触角仪对琼脂糖醋酸酯进行了表征。结果表明,琼脂糖C6上引入了乙酰基,随取代度增大,琼脂糖醋酸酯膜表面粗糙度增大,疏水性增强。纺成丝后在水中不溶胀,形态保持完好,吸湿率最小可达52.5%。随取代度的提高,白蛋白的吸附量升高,并有促进细胞粘附和增殖的功能。表明疏水改性琼脂糖可望作为新型组织再生支架材料。
A bioactive agarose acetate was prepared via the hydrophobic modification of acetic anhydride on agarose.Fourier transform infrared spectrum（FT-IR）,13C nuclear magnetic resonance spectrum（13C-NMR）,atom force microscope and contact angle were applied to the characterization of agarose acetate.The results indicate that acetyl groups are introduced into C6 of agarose and the roughness rate of agarose acetate membrane increases with higher substitution degree.The agarose acetate has the spinnability,and the fiber is not swelled,and their adsorbing rates of water can reach the minimum value,52.5%.The agarose acetate was prone to adsorb BSA protein,and fibroblasts adhered and proliferated on agarose acetate membrane very well.These findings prove that the agarose acetate is hopeful to be used as the tissue engineering scaffold.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2011年第4期67-70,共4页
Polymer Materials Science & Engineering
基金
863计划(2007AA09Z436)
广东省科技计划(2010B031100015)
广州市科技计划(2010)
NNSFC(31070853)
