摘要
纤溶系统失衡参与了缺血性卒中的病理生理学过程。大多数学者认为缺血性卒中患者的纤溶活性降低，而部分学者认为其纤溶活性增高。亚低温是一种具有巨大潜能并通过多种机制发挥神经保护效应的治疗手段。动物实验证实，亚低温治疗能提高血浆纤溶活性并减少缺血区局部纤溶酶原激活物表达，但相关临床研究较少，而且多局限于亚低温联合其他治疗方法的安全性和协同性的研究。
The imbalance in the fibrinolytic system participates in the pathophysiological processes of ischemic stroke. Most researchers consider that the fibrinolytic activity decreases in patients with ischemic stroke, while others believe that it increases. Mild hypothermia is a therapeutic approach with great potential and plays the neuroprotective effect through a variety of mechanisms. Animal experiments have demonstrated that the treatment with mild hypothermia may increase the plasma fibrinolytic activity and decrease the expression of local plasminoggen activator in ischemic area. Howere, the related clinical research studies are few, and most of them are limited in the safty and collaborative research of mild hypothermia combined with other treatment therapies.
出处
《国际脑血管病杂志》
北大核心
2011年第4期307-309,共3页
International Journal of Cerebrovascular Diseases
关键词
低温
人工
卒中
脑缺血
组织型纤溶酶原激活物
纤溶酶原激活物抑制物1
Hypothermia, induced
Stroke
Brain ischemia
Fibrinolysis
Tissue plasminogen activator
Plasminogen activator inhibitor 1
