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microRNA与前列腺癌的发生和转移 被引量：10

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摘要 前列腺癌（prostaticcarcinoma，PCA）是泌尿系统常见肿瘤，随着我国人口老龄化和饮食结构的改变，近年来其发病率有明显上升趋势。PCA发病率在不同种族间有较大差异，主要影响因素有遗传因素，环境与饮食凶素等。有统计显示，在我国被确诊为PCA的患者中有高达75％已出现远处转移，而25％-50％的患者存活期不超过5年，因此早期诊断和早期治疗是关键。
作者 许泼实
机构地区 河南省人民医院检验科
出处 《中华临床医师杂志（电子版）》 CAS 2011年第5期228-232,共5页 Chinese Journal of Clinicians(Electronic Edition)
基金 河南省科技厅重点攻关课题(102102310083)
关键词 MICRORNA 前列腺癌 远处转移 饮食结构 人口老龄化 泌尿系统 遗传因素 影响因素
分类号 R737.25 [医药卫生—肿瘤]
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参考文献47

  • 1Amling CL,Blute ML,Bergstralh EJ,et al.Long-term hazard of progression after radical prostatectomy for clinically localized prostate cancer:continued risk of biochemical failure after 5 years.J Urol,2000,164:101-105.
  • 2Craft N,Chhor C,Tran C,et al.Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.Cancer Res,1999,59:5030-5036.
  • 3Porkka KP,Pfeiffer MJ,Waltering KK,et al.MicroRNA expression profiling in prostate cancer.Cancer Res,2007,67:6130-6135.
  • 4Tong AW,Fulgham P,Jay C,et al.MicroRNA profile analysis of human prostate cancers.Cancer Gene Ther,2009,16:206-216.
  • 5Volinia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defines cancer gene targets.Proc Natl Acad Sci U S A,2006,103:2257-2261.
  • 6Mattie MD,Benz CC,Bowers J,et al.Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies.Mol Cancer,2006,5:24.
  • 7Noonan EJ,Place RF,Pookot D,et al.miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.Oncogene,2009,28:1714-1724.
  • 8He L,He X,Lim LP,et al.A microRNA component of the p53 tumour suppressor network.Nature,2007,447:1130-1134.
  • 9Tarasov V,Jung P,Verdoodt B,et al.Differential regulation of microRNAs by p53 revealed by massively parallel sequencing:miR-34a is a p53 target that induces apoptosis and G1-arrest.Cell Cycle,2007,6:1586-1593.
  • 10Fujita Y,Kojima K,Hamada N,et al.Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells.Biochem Biophys Res Commun,2008,377:114-119.

同被引文献129

  • 1蒋海锋,薄隽杰.MicroRNA与膀胱癌的研究进展[J].中国癌症杂志,2011,21(4):308-312. 被引量：4
  • 2徐彪,朱彦君.microRNA与肺癌[J].中华临床医师杂志（电子版）,2011,5(21):6406-6408. 被引量：1
  • 3Hong-He Zhang,Xian-Jun Wang,Guo-Xiong Li,En Yang,Ning-Min Yang.Detection of let-7a microRNA by real-time PCR in gastric carcinoma[J].World Journal of Gastroenterology,2007,13(20):2883-2888. 被引量：48
  • 4Bartel DP. MicroRNAs : Genomics, biogen- esis, mechanism, and function. Cell, 2004, 116:281-297.
  • 5Pieter BK, Shintaro I, Yukihide T. The mi- croRNA pathway and cancer. Cancer Sci- ence ,2010,101:2309-2315.
  • 6Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-d encodessmall RNAs with antisense complementari- ty to lin-14. Cell, 1993,75 : 843-854.
  • 7Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 andmiRl6 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A, 2002, 99: 15524-15529.
  • 8Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A ,2004,101:2999-3004.
  • 9Jody CC, Peter AJ. Epigenetics and mi- croRNAs. Pediatric Res, 2007,61 : 24R- 29R.
  • 10Syunsuke N, Takashi M, Yuki H, et al. MicroRNA-143 functions as a tumor sup- pressor in human bladder cancer T24 cells. Cancer Lett ,20l 1,307:211-220.

引证文献10

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中华临床医师杂志（电子版）
2011年 第5期

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