摘要
目的 使用左炔诺孕酮官内缓释系统（LNG-IUS）治疗子宫内膜异位症（EMS）并评价其疗效.方法 对53例EMS患者于经期末官腔放置LNG-IUS,放置后3、6、12个月观察其疗效,并进行比较.结果 放置LNG-IUS后3、6、12个月患者痛经、深部性交痛、经期肛门抽痛评分均较放置前显著降低（P＜0.05）.放置后12个月CA125[（21.8±12.5）kU/L]及雌二醇[（78.8±45.5）ne/L]较放置前及放置后3、6个月明显改善[CA125：（36.3±17.5）、（33.5±15.6）、（28.2±11.7）kU/L,雌二醇：（40.4±28.6）、（42.5±31.5）、（56.5±36.2）ng/L]（P＜0.05）.放置后6、12个月患者月经量较放置前明显减少（P＜0.05）,生活质量明显改善（P＜0.05）.结论 LNG-IUS作为释放微量孕激素的缓释系统可以安全有效地治疗EMS,不良反应小.
Objective To evaluate the efficacy of levonorgestrel-releasing intrauterine system（LNGIUS） in the treatment of endometriosis. Methods Fifty-three patients suffering from endometriosis were placed LNG-IUS in uterine cavity after menstruation. The efficacy 3,6,12 months after LNG-IUS placement was observed and compared. Results The scores of dysmenorrhea, deep dyspareunia, menstrual anus pain 3,6,12 months after LNG-IUS placement were lower than those before LNG-IUS placement （P 〈 0.05 ）.CA125 [（21.8±12.5） kU/L]and destradiol [（78.8±45.5）ng/L] 12 months after LNG-IUS placement were improved than those before LNG-IUS placement and 3,6 months after LNG-IUS placement [CA 125：（36.3±17.5）, （33.5±15.6）, （28.2 ± 11.7） kU/L,destradiol： （40.4 ± 28.6）, （42.5 ± 31.5）, （56.5 ± 36.2） ng/L]（P 〈 0.05 ）. The menstrual blood volume was less 6,12 months after LNG-IUS placement than that before LNG-IUS placement （P〈0.05）, and the quality of life was improved（ P 〈 0.05 ）. Conclusion LNG-IUS can be safe and effective treatment of patients with endometriosis, and less side effects.
出处
《中国医师进修杂志》
2011年第12期15-17,共3页
Chinese Journal of Postgraduates of Medicine
