摘要
目的探讨Creutzfeldt-Jakob病(Creutzfeldt-Jakob disease,CJD)临床特点及神经影像学表现。资料与方法回顾性分析和总结2例CJD病患者的临床表现及影像学特点、脑电图改变等资料,并复习文献。结果 2例患者均表现为基底核及多部位的灰质皮层扩散加权成像(DWI)高信号,T1WI未见异常信号,T2WI和液体衰减反转恢复序列(FLAIR)呈稍高信号,脑电图异常及脑脊液14-3-3蛋白阳性。结论 DWI显示皮层灰质和(或)纹状体信号增高,对CJD的早期诊断具有高度的敏感性。在具有相关临床症状而常规MRI不能解释的脑部检查中,DWI检查可能会发现异常信号。
Objective To investigate the clinical and neuroimaging characteristics of Creutzfeldt-Jakob disease（CJD）. Materials and Methods The clinical manifestation, electroencephalogram （EEG） and neuroimaging of two cases with CJD were analyzed retrospectively and associated literatures were reviewed. Results Two cases showed bilateral lesions in both the cerebral cortex and the basal ganglia, high signal intensity on Diffusion weighted images （DWI）, slightly high signal-in- tensity on T2WI and fluid-attenuated recovery（FLAIR） images, iso signal intensity on T1WI. The cerebrospinal fluid （CSF） was positive for the 14-3-3 protein and the Electroencephalogram（EEG） was abnormal. Conclusion DWI display bilateral high signal intensity in the cerebral cortex and/or striatum, which is a highly sensitive and specific examination for early diagnosis of CJD.
出处
《临床放射学杂志》
CSCD
北大核心
2011年第3期444-447,共4页
Journal of Clinical Radiology
