摘要
目的检测有高血压家族史的健康子女血浆E选择素（E-selectin）、血管紧张素Ⅱ（AngⅡ）及降钙素基因相关肽（CGRP）水平,探讨其在高血压发病机制中的作用。方法随机选择60例有高血压家族史的健康子女为研究组,其中父亲或母亲一方患高血压的30例为单亲组,双亲均患高血压的30例为双亲组,以双亲均无高血压的健康子女30例为对照组。用酶联免疫吸附法测定血浆E-selectin含量,用放射免疫法测定血浆AngⅡ、CGRP含量。结果研究组血浆E-selectin、AngⅡ、CGRP含量均高于对照组,差异有统计学意义（F=14.43~16.63,q=3.52~8.15,P〈0.05）;双亲组血浆E-selectin、AngⅡ、CGRP含量均高于单亲组,差异有统计学意义（q=3.12~3.98,P〈0.05）。研究组血浆CGRP与AngⅡ水平呈正相关（r=0.682,P〈0.01）。结论有高血压家族史的健康子女受遗传因素的影响,血浆E-selectin、AngⅡ、CGRP水平升高,这可能是高血压的始动因素。发现血浆E-selectin、AngⅡ、CGRP水平升高的有高血压家族史的健康子女,可能是高血压的高危对象,应积极采取一级预防措施防止高血压的发生。
Objective To study the plasma levels of E-selectin,angiotensin Ⅱ（Ang Ⅱ） and calcitonin gene-related peptide（CGRP） of healthy offsprings with a family history of essential hypertension（EH）,and explore their effects on pathogenesis of EH. Methods Sixty healthy offsprings with a family history of EH were randomly divided into two groups： 30 offsprings with one of the parents suffering from EH as group A;30 with both parents suffering from EH as group B.Another 30 healthy offsprings whose parents did not suffer from EH were assigned as control group.The plasma level of E-selectin was determined by enzyme linked immunosorbentassay（ELISA） method and the levels of Ang Ⅱ and CGRP were determined by radioimmunoassay.Results The plasma levels of E-selectin,Ang Ⅱ and CGRP were significantly higher in groups A and B than that in the control（F=14.43-16.63,q=3.52-8.15,P0.05）.Plasma levels of E-selectin,AngⅡ and CGRP were higher in group B than that in group A（q=3.12-3.98,P0.05）.Levels of CGRP were positively correlated with that of Ang Ⅱ in groups A and B（r=0.682,P0.01）. Conclusion Due to heredity,the plasma levels of E-selectin,Ang Ⅱ and CGRP increase in the healthy offsprings with a family history of EH,which might be regarded a initiating agent for EH.Healthy children with a family history of EH and with high plasma levels of E-selectin,Ang Ⅱ and CGRP are high-risk objects of EH,an active prevention measures should be taken.
出处
《青岛大学医学院学报》
CAS
2011年第2期126-128,共3页
Acta Academiae Medicinae Qingdao Universitatis
