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贝那普利联合阿托伐他汀钙治疗原发性高血压伴高血脂的临床观察 被引量:18

Clinical observation on the efficacy of benazepril and atorvastatin calcium in treatment of primary hypertension and hyperlipemia
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摘要 目的探讨贝那普利联合阿托伐他汀钙治疗原发性高血压伴高血脂的临床疗效和安全性.方法 将80例原发性高血压伴高血脂患者随机分为观察组和对照组(各40例),观察组给予贝那普利联合阿托伐他汀钙治疗,对照给予缬沙坦联合阿托伐他汀钙治疗,治疗6个月后,观察比较两组患者血压、血脂水平和肾功能等各项指标.结果 治疗6个月后两组患者血脂水平均有明显改善,与治疗前比较,差异有统计学意义(P〈0.01),但组间比较差异无统计学意义(P〉0.05);观察组患者血压和肾功能指标好于对照组,差异有统计学意义(P〈0.05).结论 贝那普利联合阿托伐他汀钙治疗原发性高血压伴高血脂,可以使患者血压持续稳定在较低水平,能改善血脂各项指标和保护肾功能. Objective To explore the benazepril and atorvastatin calcium in treatment of primary hypertension and hyperllpemia in effect and safety. Methods 80 cases patients with primary hypertension and hyperlipemia were randomly divided into the investigation group (40 cases) and the control group (40 cases) ;The former took the benazepril and atorvastatin calcium, the latter took the valsartan and atorvastatin calcium. After six months of treatment, blood pressures,blood lipid and serum creatinine (Scr) ,blood urea nitrogen (BUN),24h urine protein were observed and compared. Results Blood lipid levels decreased after treatment in both groups, there was no significant difference between two group ( P 〉 0. 05 ) ; However, blood pressure and renal function indicators in the investigation group were better than those in the control group, there were significant difference between two group( P 〈 0. 05 ). Conclusion Benazepril and atorvastatin calcium for treating patients with primary hypertension and hyperlipemia can maintain steadily at lower level of blood pressures, improve the blood lipid indicators, protect renal function, and hence is worthy of being recommended in clinical practice.
作者 喻明书
出处 《浙江临床医学》 2011年第4期371-373,共3页 Zhejiang Clinical Medical Journal
关键词 原发性高血压 高血脂 贝那普利 阿托伐他汀钙 缬沙坦 Primary hypertension Hyperlipemia Benazepril Atorvastatin calcium Valsartan
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  • 1刘新红.贝那普利联合阿托伐他汀钙治疗原发性高血压伴高血脂的临床研究[J].现代预防医学,2012,39(22):6009-6011. 被引量:15
  • 2左小瑜,张敬一,孙燕.他汀类药物对心血管疾病的临床应用新进展及安全性[J].中华临床医学杂志,2005,6(5):53-54. 被引量:11
  • 3吴文静,柯元南,孙宁玲,余振球,杨新春,秦延莉,姜红.缬沙坦与氢氯噻嗪复方制剂治疗轻中度原发性高血压临床疗效观察[J].中日友好医院学报,2006,20(6):323-326. 被引量:17
  • 4中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:54-58.
  • 5Jantzen F, Nemann S, Wolff B, et al. Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and incereases NO synthase activity in human um- bilical vein endothelial cells [ J ]. Journal of Physiol and Pharmacol, 2007,58 ( 3 ) :503 - 514.
  • 6Tycinska AM, Janica J, Mroczko B, et al. I-Iypotensive effect of atorv- astatin in hypertensive patients:the association among flow-m func- tion[J]. Arch Med Sci,2011,7(6) :955 -962.
  • 7Kuklinska AM, Mroczko B, Musial WJ, et al. Influence of atorvasta- tin on blood pressure control in treated hypertensive, normolipemic patients - An open, pilot study [ J ]. Blood Press, 2010,19 ( 4 ) : 260 - 266.
  • 8Ruperez M, Rodrigues-Diez R, Blanco-Colio LM, et ah HMG CoA re- ductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways[ J ]. Hypertension ,2007, 50(2) :377 -383.
  • 9Dumont AS, Hyndman ME, Dumont RJ,, et aL Improvement of endo- thelial function in insulin-resistant carotid arteries treated with pravastatin [ J ]. J Neurosurg,2001,95 (3) :466 - 471.
  • 10Jiang J, Roman RJ. Lovastatin prevents development of hypertension in spontaneously hypertensive rats [ J ]. Hypertension, 1997,30 ( 4 ) : 968 - 974.

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