期刊文献+

坎地沙坦和氨氯地平对原发性高血压早期肾损害的影响 被引量:10

Effect of candesartan and amlodipine on primary hypertension with early renal damage
下载PDF
导出
摘要 目的旨在探讨坎地沙坦和氨氯地平对原发性高血压早期肾损害的疗效。方法对83例门诊原发性高血压(1级、2级)伴尿微量白蛋白阳性的患者按就诊顺序用数字随机法分为氨氯地平组(5 mg·d-1)42例和坎地沙坦组(8 mg·d-1)41例,疗程3个月。观察治疗前后血压、血肌酐(Scr)、尿微量白蛋白(UMALB)、尿α1微球蛋白(Uα1-MG)、血清胱蛋白酶抑制剂C(CystC)的变化。结果两组血压均较治疗前明显降低(P<0.01),但两组治疗后血压比较,差异无统计学意义(P>0.05);两组治疗前后Scr无统计学意义(P>0.05);两组UMALB、CystC均较治疗前降低(P<0.05),两组治疗后比较坎地沙坦组优于氨氯地平组(P<0.05);两组Uα1-MG均较治疗前明显降低(P<0.01),两组治疗后比较坎地沙坦组明显优于氨氯地平组(P<0.01)。结论坎地沙坦和氨氯地平都有良好的降压作用,并且都能降低UMALB、Uα1-MG、CystC的水平,但坎地沙坦对原发性高血压早期肾损害的保护作用优于氨氯地平。 Aim To investigate the efficacy of candesartan and amlodipine on primary hypertension with early renal damage.Methods 83 microalbuminuria positive outpatients with essential hypertension(1,2)were divided into amlodipine group(5 mg·d-1)with 42 cases and candesartan group(8 mg·d-1)with 41 cases according to the order of visits,with a course of 3 months.The difference was observed in blood pressure,Scr,UMALB,Uα1-MG and CystC before and after treatment.Results Blood pressure of the two groups descended more significantly than those before treatment(P0.01),but comparing the blood pressure between the two groups after treatment,the difference is not significant(P0.05);Scr of the two groups had no changes before and after treatment(P0.05);UMALB and CystC of the two groups are lower than those before treatment(P0.05),and the candesartan group was better than amlodipine group(P0.05).So are Uα1-MG of the two groups,with a significant drop(P0.01).Conclusion Both candesartan and amlodipine have a good antihypertensive effect to reduce levels of UMALB,Uα1-MG and CystC,but the effect of candesartan is better than that of amlodipine on primary hypertension with early renal damage.
出处 《安徽医药》 CAS 2011年第4期495-497,共3页 Anhui Medical and Pharmaceutical Journal
关键词 坎地沙坦 氨氯地平 尿微量白蛋白 尿Α1微球蛋白 血清胱蛋白酶抑制剂C candesartan amlodipine urinary microalbuminuria urinary α1-microglobulin serum cystatin C
  • 相关文献

参考文献10

  • 1刘长林 金兆清.尿微量白蛋白在糖尿病肾病中的临床意义.临床检验杂志,2004,18(3):179-181.
  • 2Redon J,Pascual JM.Development of microalbuminuria in essential hypertension[J].Curr Hypertens Rep,2006,8(2):171-7.
  • 3Leoncini G,Sacchi G,Ravera M,et al.Microalbuminuria is an integrated marker of subclinical organ damage in primary hypertension[J].J Hum Hypertens,2002,16(6):399-404.
  • 4Pontremoli R,Leoncini G,RaveraM,et al.Microalbuminuria,cardiovascular,and renal risk in primary hypertension[J].J Am Soc Nephrol,2002,13(3):169-72.
  • 5万莉莉,孙洞箫.尿蛋白及尿酶测定在高血压肾损害早期诊断的价值[J].中国保健,2007,15(4):76-77. 被引量:8
  • 6Newman DJ,Thakkar H,Edwards RG,et al.Serum cystatin C measured by automated immunoassay:a more sensitive marker of changes in GFR than serum creatinine[J].Kidney Int,1995,47:312-8.
  • 7Tanaka A,Suemaru K,Otsuka T,et al.Estimation of the initial dose setting of vancomycin therapy using cystatin C as a new marker of renal function[J].Ther Drug Monit,2007,29:261-4.
  • 8Volpe M.Microalbuminuria screening in patients with hypertension:recommendations for clinical practice[J].Int J Clin Pract,2008,2(1):97-108.
  • 9黄干.坎地沙坦酯治疗1—2级原发性高血压疗效观察[J].安徽医药,2007,11(1):19-20. 被引量:7
  • 10吴文炎.氨氯地平联用阿托伐他汀钙治疗高血压伴高血脂29例临床观察[J].中国临床保健杂志,2009,12(3):278-279. 被引量:30

二级参考文献13

共引文献49

同被引文献94

引证文献10

二级引证文献71

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部