摘要
目的:探讨甲状腺功能亢进症包括亚临床甲状腺功能亢进症与复发性自然流产的关系。方法:选择66例有复发性自然流产史的妇女为研究组(复发性自然流产组),99例健康未孕妇女为对照组。应用免疫放射方法检测FT3、FT4、TSH。结果:复发性自然流产组甲亢患者有16例,甲亢患病率为24.24%;对照组甲亢患者有9例,甲亢患病率为9.09%,复发性自然流产组甲亢患病率显著高于对照组,两组相比,差异有高度统计学意义(χ2=7.07,P<0.01)。复发性自然流产组中亚甲亢与对照组中亚甲亢患病率的比较,差异有统计学意义(χ2=4.80,P<0.05)。复发性自然流产组妇女亚甲亢的患病率(18.18%)高于临床甲亢的患病率(6.06%),两者比较,差异有统计学意义(χ2=4.55,P<0.05)。FT4水平在复发性自然流产组(18.96±5.58)μIU/ml与对照组(17.10±3.99)μIU/ml比较,差异有统计学意义(t=2.43,P<0.05)。结论:复发性自然流产组中甲亢包括亚临床甲亢的患病率明显增高,甲亢患者与其自身发生复发性自然流产有一定相的关性。FT4、TSH的异常可能是诱发复发性自然流产的原因之一。
Objective： To investigate the relationship between hyperthyroidism including subclinical hyperthyroidism with recurrent spontaneous abortion （RSA）. Methods： 66 cases of RSA women （RSA group） and 99 eases of non-pregnancy women （control group） were enrolled in the study. Serum free T3 （FF3）, free T4 （FT4） and thyrotropin （TSH） were measured by immune radiate method. Results： There were 16 cases with a hyperthyroidism in RSA group, the overall prevalence of hyperthyroidism was 24.24%; there were 9 cases with hyperthyroidism in the control group, the overall prevalence of hyperthyroidism was 9.09%, RSA group of hyperthyroidism prevalence rate was higher than that of the control group, the difference was statistically significant （X2=7.07, P〈0.01）. RSA group and control group were compared in subclinical hyperthyroidism, there was a significant difference （x^2=4.80, P〈0.05）. In RSA group the prevalence of subclinical hyperthyroidism was higher than that of clinical hyperthyroidism, there was a significant difference （18.18% vs 6.06%, x^2= 4.55, P〈0.05）. In RSA group the free T4 was at an average of （18.96±5.58） μlU/ml, the control group （17.10±3.99） μIU/ml, there was a significant difference （t =2.43, P〈0.05）. Conclusion： RSA group, hyperthyroidism including subclinical hyperthyroidism prevalence is significantly higher, in patients with hyperthyroidism occurred with its own RSA have a certain correlation. It is possible one of the reasons that the abnormal FT4 or TSH leaded to RSA.
出处
《中国医药导报》
CAS
2011年第12期18-20,共3页
China Medical Herald
