摘要
目的探讨乙肝病毒感染与淋巴瘤化疗后肝损害关系。方法分析１８２例中高度恶性淋巴瘤化疗后肝功能改变，其中携带乙肝病毒５３例，未携带者１２９例，化疗前肝功能均正常，观察化疗后肝功能变化情况。结果经过二周期以上的正规化疗后，ＨＢｓＡｇ（＋）组肝损害发生率占４５３％（２４／５３），ＨＢｓＡｇ（－）组肝损害发生率占２７１％（３５／１２９），Ｐ＜００５。ＨＢｓＡｇ（＋）组中并用利分能（重组人ａ－２ｂ干扰素）治疗１０例，肝损害发生率为１００％（１／１０），而未用利分能治疗４３例，肝损害发生率为５３５％（２３／４３），Ｐ＜００５。结论乙肝病毒感染的淋巴瘤患者化疗后易致肝损害，并用利分能治疗可减轻其损害。
Objective Observing the ralationship between HBV and liver damage in chemotherapy of Lymphoma.Methods Among 182 cases of lymphoma,53 cases with positive serum HBV marker while 129 cases without HBV marker.The liver funtion of all cases were normal before chemotherapy,effort was made to observe the patients liver function damage after chemotherapy.Results After two phases regular chemotherapy,the liver damage was 45 3% (24/53) in HBV(+) group and 27 1%(35/129) in HBV(-) group ( P <0 05).Furthermore,among the patients in HBV(+) group,10 cases were treated with Interferon alfa-2b and the others didnt use the drug.Liver function damage was 10 0%(1/10) in the former while 53 5%(24/43) in the latter ( P <0 05).Conclusion The cases with HBV(+) were more likely to appear liver function damage,which could be alleviated by using Interferon alfa-2b.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第4期268-269,共2页
Cancer Research on Prevention and Treatment
