摘要
目的探讨脉压(PP)、脉压指数(PPI)对冠心病的预测价值及其与冠状动脉病变严重程度的关系。方法纳入9847例疑诊冠心病并行诊断性冠状动脉造影的住院患者进行回顾性分析,以冠状动脉造影阳性(主要血管直径狭窄≥50%)作为诊断冠心病的标准,采用Gensini积分评价冠状动脉造影病变程度,并计数冠状动脉病变的支数。采用单因素方差分析及多因素回归分析观察PP、PPI与冠状动脉病变严重程度的关系。结果单因素分析显示,冠心病组的PP、PPI(分别为54.63±15.82、0.40±0.07)高于非冠心病组(分别为49.74±14.27、0.38±0.07,P<0.001),且冠状动脉病变严重程度(冠脉病变支数、冠脉病变Gensini积分)越高,PP、PPI值越大(P<0.001)。多因素logistic回归分析显示,PPI是冠脉造影确诊冠心病最显著的独立相关危险因素(OR=4.921,95%CI2.241～10.808,P<0.001)。结论 PP、PPI水平与冠心病明显相关;PP、PPI水平越高,冠脉病变越严重;PPI是冠脉造影确诊冠心病最显著的独立危险因素。
Objective To investigate the correlation between pulse pressure（PP）,pulse pressure index（PPI） and the severity of coronary artery lesion in patients with CAD,and evaluate the significance of PP and PPI in predicting CAD.Methods The data of 9847 patients who had undergone coronary angiography were collected.The positive coronary angiography（stenosed major vessels ≥ 50%） served as a diagnostic standard of CAD.CAD severity was assessed by Gensini score,and the number of stenosed arteries was counted.Relationship between PP,PPI and the severity of CAD was evaluated by both single factor analysis and multivariate binary logistic regression analysis.Results The CAD patients were found to have higher PP（54.63±15.82 vs 49.74±14.27,P〈0.001） and PPI（0.40±0.07 vs 0.38±0.07,P〈0.001）.Furthermore,the severity of CAD were associated with increased PP and PPI.Binary logistic regression analysis showed that PPI was a prominent predictor of the CAD（OR=4.921,95%CI 2.24110.808,P〈0.001）.Conclusion The levels of PP and PPI are significantly correlated with CAD;PPI is the most prominent predictor in diagnosis of CAD.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2011年第4期319-322,共4页
Medical Journal of Chinese People's Liberation Army
基金
"十一五"国家科技支撑计划项目(2006BAI01A02)
关键词
血压
脉压指数
冠状动脉疾病
危险因素
blood pressure； pulse pressure index； coronary disease； risk factors；
