摘要
目的探讨乙醛脱氢酶1(Aldehyde Dehydrogenase 1,ALDH1)在结肠癌组织中的表达及其临床意义。方法应用免疫组化SP法检测98例结肠癌组织和15例癌旁组织中ALDH1蛋白的表达情况,分析ALDH1蛋白的表达与临床病理因素的关系及对结肠癌预后的影响。结果 ALDH1蛋白在结肠癌组织中的表达率为76.5%(75/98),癌旁组织中表达率为13.3%(2/15),两者具有统计学差异(P<0.05)。ALDH1表达与结肠癌的组织分化程度、临床分期、淋巴结转移密切有关,该3因素的分组间差异有统计学意义(P<0.05)。ALDH1阴性组结肠癌患者的预后明显好于阳性组患者。结论 ALDH1在结肠癌发生、发展中具有重要作用,可能成为结肠癌诊断的新的生物标志物和判断其生物学行为、预测转移趋势及预后的有价值指标。[中国普通外科杂志,2011,20(3):269-272]
Objective To study the expression of ALDH1 in colon cancer and its clinical significance. Methods The expression of ALDH1 was examined in 98 surgical specimens of primary colonic carcinoma and 15 adjacent cancer tissues with immunohistochemistry method.The correlations of the ALDH1 expression with clinicopathological parameters and prognosis of colon cancer were analyzed. Results The positive rate of expression of ALDH1 was 76.5%（75/98） in cancer tissues and 13.3%（2/15） in adjacent cancer tissues.There was an obvious statistical difference（P0.05） between the two groups.The ALDH1 expression was significantly correlated with the histological grade,TNM stages and lymph node metastasis of colon cancer（P0.05）.It was also related with patients′survival time,and those with positive expressions had a poor prognosis（P0.05）. Conclusions The results suggest that the overexpression of ALDH1 plays important role in development and progression of colon cancer,and ALDH1 may be a valuable marker to predict the biological behavior and trend of metastasis of colon cancer.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2011年第3期269-272,共4页
China Journal of General Surgery
