摘要
目的:探讨鼻窦灌注液冲洗对慢性鼻窦炎鼻内镜术后的疗效机制。方法:行鼻窦内窥镜手术的100例慢性鼻窦炎患者,随机分为治疗组和对照组,各50例。观察两组内镜术后炎性黏膜纤毛功能、Thl/Th2细胞因子以及嗜酸性粒细胞的情况。结果:治疗后3月,治疗组和对照组患者的纤毛传输速率较治疗前均有显著提高(P<0.01),两组手术治疗3个月后IFN-r、IL-4、IL-5的含量均出现明显下降(P均<0.01),治疗组与对照组比较IFN-r、IL-4、IL-5差异有统计学意义(P<0.01);治疗后IL-2含量两组比较差异无统计学意义(P>0.05)。治疗组和对照组均有减少嗜酸性粒细胞浸润数量的作用(P<0.05);两组对嗜酸性粒细胞的减少无明显差别,差异无统计学意义(P>0.05)。结论:术腔冲洗是慢性鼻窦炎鼻内镜术后综合处理中的关键措施,能有效促进术腔黏膜纤毛超微结构和功能的恢复;能有效地减轻炎症反应,消除黏膜水肿,恢复其自身保护和防御功能;能通过调理患者术后的全身机能状态,使Thl/Th2网络系统恢复相对应的健康平衡状态。
Objective： To investigate the effect of sinus perfusate flushing on treating chronic sinusitis after nasal endoscopic surgery.Methods： A total of 100 cases with chronic sinusitis treated by nasal endoscopic surgery were randomly divided into treatment group and control group by half.The function of inflammatory mucosal cilia,status of Thl/Th2 cell factors and eosinophilic cell were observed and compared.Results： Three months after treatment,the transmission rate of inflammatory mucosal cilia was improved significantly（P〈0.01）.There was no significant difference in IL-2（P〉0.05）.The infitration of eosinophilic cells decreased in two groups significantly（P〉0.05）,while there was no significant difference in number of eosinophilic cells（P〉0.05）.Conclusion： Cavity flushing is effective treatment of chronic sinusitis after endoscopic surgery.It can promote the recovery of ultrastructure and function of mucous cilia,relieve inflammation,eliminate mucosa edema,restore autoprotective and defensive function,regulate general status of patients,and make the relative balance of Thl/Th2 network system.
出处
《海南医学院学报》
CAS
2011年第4期555-557,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110130)~~
关键词
鼻窦灌注液冲洗
慢性鼻窦炎鼻内镜术
疗效
Sinus perfusate flushing,Chronic sinusitis； Nasal endoscopic surgeryn； Curative effect；
