摘要
目的观察羟氯喹(hydroxychloroquine)对痛风关节炎患者血尿酸的影响及安全性。方法将2009年1月-2010年4月期间在我院风湿科门诊就诊的43例原发性痛风患者随机分为治疗组26例和对照组20例。治疗组采用一般治疗、控制尿酸药物及羟氯喹治疗,对照组采用一般治疗、控制尿酸药物及小剂量秋水仙碱治疗。治疗前及治疗后1、3、6个月,检测两组患者的外周血血清尿酸和血脂水平。结果治疗后3、6个月末与治疗前对比,两组病人血清HDL下降差异均有意义(P<0.01),治疗后3个月末与治疗前对比,两组病人血脂TC、LDL、UA水平下降差异有意义(P<0.05),治疗后6个月月末,治疗组与对照组间TC、LDL、UA差异均有统计学意义(P<0.01)。急性痛风性关节炎复发次数减少差异无统计学意义(P>0.05)。结论羟氯喹可减少痛风关节炎的发作次数及降低血尿酸、血脂,具有较好耐受性和安全性;
Objective To observe the impact and safety of hydroxychloroquine（HCQ） on serum uric acid in gout arthritis.Methods 43 rheumatology clinic patients with primary gout who were treated in our hospital during January 2009 to April 2010 were randomly divided into treatment group（26 cases） and control group（20 cases）.Treatment group accepted the general treatment,controlling uric acid and hydroxychloroquine.Control group accepted the general treatment,controlling uric acid and small dose of colchicine.Serum uric acid and lipid levels of patients were detected before treatment and after 1,3,6 months of treatment.Results Both groups of patients had significant difference in serum HDL concentration decrease between pretreatment and 3,6 months after treatment（P0.05）.At the end of the 3 month,blood TC,LDL,UA levels decreased significantly（P0.05）.At the end of the 6 month,blood TC,LDL,UA levels decreased significantly（P0.01）.Acute gouty arthritis and reduction of the frequency of recurrence had no significant difference（P0.05）.Conclusion HCQ can reduce the number of attacks of gout arthritis and decrease blood uric acid and blood lipids with good tolerability and safety.
出处
《成都医学院学报》
CAS
2011年第1期66-68,共3页
Journal of Chengdu Medical College
关键词
羟氯喹/治疗应用
代谢/治疗
hydroxychloroquine /treatment
metabolism/treatment
