摘要
目的:探索γ-巯丙基键合硅胶(γ-mercaptopropyl-modified silica gel,MPS)脱除金银花药液中铅离子的吸附规律和最佳工艺。方法:采用静态吸附和动态吸附的方式考察铅的脱除率,并以药液含固量、HPLC指纹图谱和指标成分含量为指标,比较脱铅的过程中,药液化学成分的变化情况。结果:静态吸附表明,MPS吸附药液中铅的速度很快,铅的脱除率达到80%。动态吸附的铅脱除效果优于静态吸附,最佳脱铅的工艺为上样量为6个柱体积药液,柱径高比1∶10,洗脱速度6 BV.h-1,温度25℃。脱铅过程中,药液含固量、HPLC指纹图谱及指标成分的含量无明显变化。结论:γ-巯丙基键合硅胶可以有效地脱除金银花药液中的铅离子。
Objective：To remove plumbum ion from the extract of Lonicera japonica by γ-mercaptopropyl-modified silica gel（MPS）.Method： The reference plumbum ion solution was added into the extract of L.japonica as the tested samples.The static and dynamic adsorptions were investigated to evaluate the influent factors on the removal of plumbum ion in the extract.The solid content and HPLC profiles of the extract were determined to evaluate the process changes.Result： MPS showed excellent adsorption charateristics to remove plumbum ion from the extract of L.japonica,with fast adsorption rate and more than 80% removal efficiency.The optimum parameters were as follows： 6 times sample volume,10 times of height to diameter,and 6 BV·h-1 of flow velocity,at the temperature of 25 ℃.During the removal process,obvious changes of solid content and HPLC profiles were not observed.Conclusion： MPS could be used to remove plumbum ion from extract of L.japonica.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第9期1179-1182,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09301-005
2009ZX09308-003)
中国中医科学院自选课题(ZZ2009020201)
关键词
γ-巯丙基键合硅胶
金银花
重金属
铅
γ-mercaptopropyl modified silica gel（MPS）； Lonicera japonica； heavy metal； plumbum；
