摘要
目的探讨稳定期慢性阻塞性肺疾病（COPD）患者血清白介素-6（IL-6）与6分钟步行距离的关系。方法 2009年12月至2010年12月收集稳定期COPD患者50例,测定6分钟步行距离（6MWD）;同时选择10例健康志愿者作对照,用ELISA法检测COPD患者和健康志愿者血清IL-6。分析COPD患者血清IL-6与六分钟步行距离的相关性。血清IL-6经对数转换后应用SPSS16.0统计软件进行统计学分析。结果稳定期COPD患者血清IL-6水平[4.34（3.31~5.5）pg/ml]高于健康对照组[2.36（1.42~3.56）pg/ml],两组比较差异有统计学意义（t=-5.2,P=0.000）。log IL-6与6MWD呈负相关（r值=-0.578,P〈0.01）。结论血清IL-6在稳定期COPD患者中增高,可在一定程度上反应COPD的全身炎症程度,并且与COPD患者的运动能力相关,可作为预测稳定期COPD患者病情及生活质量的有效指标。
Objective To investigate the relationship between Interleukin-6（IL-6） levels and 6-min walk distance in stable chronic obstructive pulmonary disease（COPD） patients.Methods Between December 2009 and December 2010,50 stable COPD patients to recruit,we evaluated exercise capacity,using 6-min walk distance（6MWD）;IL-6 levels were measured in these patients and in 10 controls.Studying the relationship between IL-6 levels and 6MWD.After logarithmic transformation of IL-6,the data were analyzed using a statistical software package（SPSS 16.0）.Results IL-6 levels were higher in COPD patients[4.34（3.31～5.5））pg/ml ]than controls [2.36（1.42～3.56）pg/ml].The sputum log IL-6 levels was negatively correlated with 6MWD（r=-0.578,P0.01）.Conclusions IL-6 levels were higher in stable COPD patients and can represent systemic inflammation to some degree.IL-6 levels were correlated with exercise ability.This should be considered when IL-6 levels are measured in stable chronic obstructive pulmonary disease patients.
出处
《医药论坛杂志》
2011年第4期51-52,55,共3页
Journal of Medical Forum
