摘要
目的探讨新生儿全身炎症反应综合征(SIRS),中外周血IL-6,TNF-α表达变化,从而了解SIRS发展过程中二者水平变化及其相关性。方法采用免疫组化法检测45例SIRS组及45例非SIRS组血清中IL-6,TNF-α水平。结果 IL-6,TNF-α在SIRS组中表达率86.66%(39/45),明显高于非SIRS组22.22%(10/45),二者比较差异有显著性(P<0.05)。IL-6,TNF-α表达在不同性别患儿之间差异无显著性(P>0.05);IL-6,TNF-α表达在SIRS组中明显高于非SIRS组(P<0.05)。结论 IL-6,TNF-α参与了患儿SIRS发展过程,这为患儿SIRS的诊断、治疗提供新的策略与途径。
Objective To explore peripheral IL-6 and TNF alpha expression changes in the neonatal systemic inflammatory response syndrome（SIRS）,thus learning the level changes and their correlation in SIRS development process.Methods By immunohistochemical method to detect 45 cases SIRS group and non SIRS group 45 patients serum IL-6,TNF alpha level.Results IL-6,TNF alpha in SIRS group expression rate 86.66%（39/45）,significantly higher than non SIRS group 22.22%（10/45）,both comparative group（P0.05）.IL-6,TNF alpha expression with non-significant（P0.05） in between different gender children.IL-6,TNF alpha expression in SIRS significantly higher than non SIRS group（P0.05）.Conclusions IL-6,TNF alpha participated in the development process of the children SIRS,this for children SIRS the diagnosis,treatment,provide new strategies and methods.
出处
《医药论坛杂志》
2011年第4期91-92,共2页
Journal of Medical Forum
