摘要
将 ６８只 ＳＤ大鼠双侧颈总动脉切断造成急性不完全性脑缺血的实验性血管性痴呆（ＶＤ）模型，随机分为模型组（３４只）、电针组（３４只），与假术组作对照（３５只）。分别检测三组的自发运动量、避暗学习反应能力、超氧化物歧化酶（ＳＯＤ）、皮质醇（Ｃｏｒｔｉｓｏｌ）以及脑皮质、纹状体、海马、下丘脑的去甲肾上腺素（ ＮＥ）、多巴胺（ ＤＡ）、 ５－羟色胺（ ５－ＨＴ）含量。结果发现，模型组、电针组的自发运动量、避暗学习反应能力、ＳＯＤ指标降低（ Ｐ＜ ０． ００１），而电针组高于模型组（ Ｐ＜ ０． ０５～０．０１）。实验提示，电针能提高实验性ＶＤ大鼠的自发运动量和避暗学习反应能力，与改善脑循环，提高ＳＯＤ、Ｃｏｒｔｉｓｏｌ、ＮＥ、ＤＡ、５－ＨＴ的活性密切相关。
68 Sprague-Dawley rats were prepared to acute, incomplete cerebral ischemia by cutting off bilateral carotid arteries, and the animal models of vascular dementia(VD) were made. Then they were divided randomly into ischemic group(Isch, 34 cases)and electroacupunture group(EA, 34 cases). In our study, we respectively detected the amount of autonomic activity, the response ability of learning escape dark, the contents of blood superoxide dismutase(SOD), blood cortisol, norepinephrine(NE), dopamine (DA), 5-hydroxytryptamine(5-HT) in cortex, striatum, hippocampus and hypathalamus. Results: the amount of autonomic activity, the response ability of learning escape dark, SOD in Isch and EA group decreased significantly (P < 0. 001) as compared with the control group (35 cases), but those in EA group were much higher than those in Isch group (P < 0. 05-0.01 ). Conclusion: Electroacupuncture can promote the amount of autonomic activity and the response ability of learning escape dark in the animal model of VD, which closely related with improving the cerebral circulation, enhancing the ability of SOD, cortisol, NE, DA and 5-HT.
出处
《针刺研究》
CAS
CSCD
1999年第3期192-197,共6页
Acupuncture Research
基金
广东省中医药管理局科研基金!(编号:940123)
广东省自然科学基金!(编号:960548)
