凝血栓蛋白1在肿瘤发生和转移中的作用被引量：1

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摘要凝血栓蛋白1（thrombospondin-1,TSP-1）于20世纪70年代首次被发现,主要储存在血小板的α颗粒内,在血小板被激活时释放。TSP-1与同家族成员TSP-2都具有Ⅰ型重复单位,在肿瘤微环境中具有抗血管生成的作用,而家族成员TSP-3,-4和-5不具有此种结构和功能。研究发现,TSP-1在不同肿瘤的发展中起到的作用不一致,在同一种肿瘤的不同发展时期,TSP-1的抑癌和促癌作用也不一致。

作者于妍妍陈东风

机构地区第三军医大学学员旅第三军医大学大坪医院消化内科

出处《重庆医学》 CAS CSCD 北大核心 2011年第14期1411-1413,共3页 Chongqing medicine

关键词转化生长因子Β 肿瘤凝血栓蛋白1基因血管发生

分类号 R730.2 [医药卫生—肿瘤]

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