摘要
目的 探讨各年龄组儿童正常血清铋浓度及服用治疗剂量胶体次枸橼酸铋（ＣＢＳ）的安全性。方法 用原子荧光光谱法测定９７ 例１～１２ 岁正常儿童血清铋浓度和９４ 例５ ～１２ 岁经胃镜检查确诊为幽门螺杆菌（Ｈｐ）相关性胃十二指肠疾病的儿童，服ＣＢＳ６ 周，合并阿莫仙和甲硝唑各服２ 周的治疗方案后，进行服ＣＢＳ后１、２、４、６ 周和停服后１ 周、１～２ 个月、３～４ 个月、５～６ 个月和６ ～１２ 个月以上血清铋浓度的观察。结果 （１）正常儿童血清铋浓度在各组间经统计，Ｆ＝ １３．７５，Ｐ＝０．０００ １，差异有非常显著意义。本组正常儿童血铋浓度从１ 岁始随年龄增长而增高，５～６ 岁组到１２ 岁保持相对恒定。（２）服ＣＢＳ后各组血清铋浓度经统计，Ｆ＝３７．１８，Ｐ＝０．０００ １，其中４ 周、６ 周两组与１ 周、２ 周两组间差异有显著意义（ Ｐ＜ ０．０５），服药后血铋浓度逐渐上升，４ 周后不再继续升高，平均在（１０．２ ±２．４）μｇ／Ｌ或（１０．８±２．１） μｇ／Ｌ，远未达到临界浓度（５０～１００ μｇ／Ｌ）。（３）停药后各组血铋浓度经统计，Ｆ＝２２．１１，Ｐ＜０．０００ １，各组均数间两两比较差异也有显著意义（ Ｐ＜ ０．０５）。
Objective To determine the value of serum bismuth concentration in normal children and the safety of colloidal bismuth substrate (CBS) of treating dosage Methods The atomic fluorescent spectrometry was used to determine the serum bismuth concentration in 97 normal children aged from 1 to 12 years and 94 children patients aged 5 to 12 years who were diagnosed by gastroscopy as suffering from Helicobacter pylori related gastroentestinal diseases The patients were treated with a program of taking CBS for six weeks, combined with amoxicillin two weeks and metronidazole two weeks To observe the trend of serum bismuth concentration, the observations were conducted for one, two, four and six weeks after taking CBS Then one week, one to two months, three to four months, five to six months and over six months after stopping CBS treatment the observations were conducted again Results (1) The serum bismuth concentrations of normal children among different age groups were significantly different ( F =13 75, P = 0 000 1) Serum bismuth concentrations of the normal children increased with age and were relatively stable after 5 6 years of age (2) The serum bismuth concentration in different groups of patients taking CBS showed F =37 18, P = 0 000 1 There were significant differences between the 4 week, 6 week groups and the 1 week, 2 week groups, P <0 05 Serum bismuth concentrations gradually elevated 4 weeks after taking the CBS with an average level of (10 2±2 4) or (10 8±2 1) μg/L, which was far lower than the critical value (50～100 μg/L) (3) Serum bismuth concentrations declined very slowly after the CBS treatment was discontinued Returning to the normal level required 6 to 12 months, which is longer than the process in adults (4) The overall effectiveness of combined therapy with the 3 agents, was 95%, the eradication rate of Hp was 86 % The side effect occurred in 5% of the cases Conclusion It is safe for children to take CBS of treatment dosage and the bismuth toxicosis may not occur Using the combined therapy containing CBS to treat children with Hp related gastroentestinal disease may bring satisfying results
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1999年第9期555-558,共4页
Chinese Journal of Pediatrics
关键词
胃疾病
幽门螺杆菌
铋
十二旨肠疾病
儿童
Stomach diseases Helicobacter pylori Bismuth Duodenal diseases
