摘要
目的探讨益肺康心胶囊对大鼠肺心病模型碱性成纤维细胞生长因子(bFGF)的影响。方法将60只SD大鼠分为空白组、模型组、中药组、对照组,每组15只。治疗组给予益肺康心胶囊,对照组给予卡托普利,每日1次。连续给药15d,至检查前24h停药。分别于停药后的7、14、28d处死大鼠,作肺组织bFGF测定。结果治疗组经益肺康心胶囊治疗后肺组织bFGF表达明显下降,低于模型组。结论益肺康心胶囊可明显抑制大鼠肺心病模型bFGF的表达。
Objective：To discuss the influence of Yifeikangxin Capsule on bFGF of rats model with corpulmonale.Methods：The 60 SD rats with corpulmonale were averagely grouped as the normal group,the model group,the Chinese herbs group and the control group.The rats in the Chinese herbs group were given Yifeikangxin Capsule and the rats in the control group were given captopril.The course of treatment was 15 days.The rats were killed on the next 7th,14th and 28th day separately to test bFGF in pulmonary tissue.Results：After the Yifeikangxin Capsule,the expression of bFGF in pulmonary tissue of the Chinese herb group was lower than it in the model group.Conclusion：Yifeikangxin Capsule can inhibit the expression of bFGF in the rats model with corpulmonale.
出处
《中国中医急症》
2011年第5期745-745,753,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
黑龙江省中医管理局科研项目(ZHY08-W45)
关键词
肺心病
益肺康心胶囊
碱性成纤维细胞生长因子
肺血管重构
Corpulmonale
Yifeikangxin Capsule
Basic fibroblast growth factor
Pulmonary vascular remodeling
