摘要
目的探讨α-干扰素联合高三尖杉酯碱加阿糖胞苷(HA)治疗慢性粒细胞白血病(CML)的临床疗效。方法以内江市二人民医院27例CML患者为治疗组,以同期收治的21例CML患者为对照组。治疗组给予干扰素联合HA治疗;对照组给予α-干扰素及口服羟基脲,比较两组临床疗效。结果两组无效率差异无统计学意义(P>0.05);治疗组的部分缓解率低于对照组,治疗组的完全缓解率明显高于对照组,差异均有统计学意义(P<0.05)。在治疗初期,两组不良反应的发生率差异无统计学意义(P>0.05)。结论α-干扰素联合HA治疗CML是一种合理、经济且有效的方法。
Objective To investigate the clinical performance of interferon-α combined with HA solution on treating with chronic myeloid leukemia（CML）.Methods 27 cases of CML in our hospital were taken as the therapeutic group,21 cases of CML were taken as the control group in the same period.The therapeutic group was given interferon combined with HA treatment.The control group was given interferon-α and oral hydroxyurea treatment.The performances of the two kinds of treatments in different groups were compared.Results The noneffective rate in 2 groups was not statistically different（P〉0.05）.The rate of partial remission in the therapeutic group was lower than that in the control group.The rate of complete remission in the therapeutic group was higher than that in the control group.The differences were all statistically significant（P〈0.05）.The result of occurrence rate of adverse reactions in the 2 groups was not statistically difference（P〉0.05）.Conclusion Interferon-α combined with HA solution was a proper,economical and effective therapeutic method for CML.
出处
《检验医学与临床》
CAS
2011年第9期1055-1056,共2页
Laboratory Medicine and Clinic
