摘要
目的观察阿托伐他汀钙对急性脑梗死患者颈动脉粥样斑块硬化的治疗作用。方法 120例有颈动脉斑块形成的急性脑梗死患者随机分为治疗组和对照组,各组60例,均给予常规和综合性治疗,治疗组给予阿托伐他汀钙片,20 mg,1次/晚,治疗12个月,观察2组患者颈动脉斑块的内膜中层厚度(IMT)和斑块面积,血脂水平和高敏C-反应蛋白(hs-CRP)浓度。结果治疗组应用阿托伐他汀钙12个月,其颈动脉IMT斑块面积、血脂水平、hs-CRP均显著下降,治疗组治疗后的IMT与治疗前显著降低,差异有统计学意义(P<0.05)。结论阿托伐他汀钙可以显著稳定动脉斑块,并促进斑块的消退,减轻血管的炎症反应。
Objective To investigate the effect of atovatarstin calcium on carotid atherosclerosis plaques in patients with acute cerebral infarction（ACI）.Methods One hundred and twenty patients with ACI were randomly divided into control group and atovastin calcium treatment group,control group was treated with routine method and treatment group was treated with atovarstatin calcium 20 mg every night for twelve months.The maximal intima-media thickness,the blood fat and high sensitivity C-reactive protein were measured.Results After the treatment of 12 months,carotid artery IMT and size of plaque,the blood fat and the hs-CRP were significantly decreased.Conclusion Atovarstatin calcium could retard the progressive development of carotid atherosclerosis and the carotid artery plaque could be regressed.
出处
《中国实用神经疾病杂志》
2011年第8期6-8,共3页
Chinese Journal of Practical Nervous Diseases
关键词
阿托伐他汀钙
急性脑梗死
颈动脉粥样斑块
高敏C-反应蛋白
Atovarstatin calcium
Acute cerebral infarction
Atherosclerosis plaques
High sensitivity C-reactive protein
