摘要
目的探讨不同的药物治疗早发型重度子痫的临床效果。方法将80例早发型重度子痫前期患者随机分为两组：尼卡地平联合治疗组（A组）40例；酚妥拉明联合治疗组（B组）40例。分别于治疗前后观察血压，血清Ca^2＋、Mg^2＋浓度和尿蛋白的变化等。结果两组用药24h平均动脉压较用药前比较下降明显（t=2．351、2．315，均P〈0．05）；两组经药物治疗后尿蛋白定量减少，但治疗前后比较差异无统计学意义（t=1．289、1．287，均P〉0．05）；治疗后各组血清Ca2^＋、Mg^2＋含量均高于治疗前（t=2．298、2．311，均P〈0．05）；A组平均维持妊娠时间比B组显著延长（X^2=3．714，P〈0．05）；Apgar评分8分以上胎儿数A组显著高于B组（X^2=3．784，P〈0．05）。结论尼卡地平联合硫酸镁治疗早发型重度子痫前期，疗效肯定，值得推广应用。
Objective To investigate the clinical effects of different drug treatment on early onset severe pre-eclampsia. Methods 80 patients with early onset severe preeclampsia were randomly divided into two groups：Pell horizon treatment（group A） 40 cases and phentolamine treatment （group B） 40 cases, blood pressure, serum Ca^2＋, Mg^2＋ concentration and protein in urine were observed before and after treatment in . Results The mean arterial blood pressupe in medication over 24 hours compared with that before treatment were significantly decreased in two groups（ t = 2. 351,2.315, all P 〈 0. 05 ） ; After treatment reduced urinary protein was observed in two groups, before and after tratment there were no significant difference（ t = 1. 289,1. 287, all P 〉 0. 05 ） ; The contents of Ca^2＋ , Mg^2＋ after treatment were higher than before treatment （ t = 2.298,2.311, P 〈 0.0） ; The time of average pregnancy in group A was significantly longer thar that in group B （X^2 = 3.714, P 〈 0.05） ;The number of Apgar score more than 8 points in group A was significantly higher than the group B （X^2 = 3. 784 ,P 〈 0.05）. Conclusion Perdipine with magnesium sulfate had affirmative curative effect in the treatment of early onset severe preeclampsia,and it was deserved to be applied.
出处
《中国基层医药》
CAS
2011年第8期1048-1050,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
妊娠
子痫前期
早发型
尼卡地平
硫酸镁
Pregnancy
Preeclampsia
Early onset
Perdipine
Magnesium sulfate
