摘要
目的:探讨儿童过敏性紫癜(AP)血浆组织因子途径抑制物(TFPI)的含量及其在病程不同时期的变化趋势。方法:选择AP患儿23例设为AP组,正常健康儿童23名设为正常对照组,分别检测其血浆TFPI含量并进行比较;将AP组病例给予基础治疗,于治疗前、治疗后14 d检测其血浆TFPI含量并进行分析比较。结果:①AP组血浆TFPI含量(59.639±24.568)ng/ml比正常对照组血浆TFPI含量(88.761±12.214)ng/ml明显降低,差异有统计学意义(P=0.000<0.01);②AP组治疗后14 d血浆TFPI含量(71.209±23.055)ng/ml较治疗前(59.639±24.568)ng/ml升高,差异有统计学意义(P=0.000<0.01);显示随着时间延长,血浆TFPI呈升高趋势。结论:AP儿童血浆TFPI水平较正常儿童降低,随着病程延长呈上升趋势。
Objective:To investigate the plasma levels of Tissue Factor Pathway Inhibitor(TFPI)in children with Anaphylactoid Purpura(AP) and its variation tendency in different periods.Methods: 23 AP patients were enrolled in AP group and 23 normal healthy children as controls.The plasma levels of TFPI were measured by enzyme-linked immunosorbent assay in both groups.Applied for based treatment to AP group,the plasma levels of TFPI were measured before therapy and on the 14th day after therapy respectively.Results:①The plasma levels of TFPI in AP group(59.337±21.750 ng/ml) significantly lower than those of control group(88.761±12.214ng/ml)(P=0.0000.05).②The plasma levels of TFPI(71.209±23.055 ng/ml) on the 14th day after therapy significantly higher than the before treatment(59.639±24.568 ng/ml),difference are statistically significant(P=0.0000.01);through analysis of variance,it showed a result: as well as time went by,The plasma levels of TFPI tend to increase.Conclusions:The plasma levels of TFPI in AP patients obviously decreased,which tend to increase with the course of disease.
出处
《内蒙古医学杂志》
2011年第3期271-273,共3页
Inner Mongolia Medical Journal
关键词
过敏性紫癜
组织因子途径抑制物
儿童
Anaphylactoid purpura
Tissure factor pathway inhibitor
Child