摘要
目的:探讨SonoVue实时超声造影在乳腺癌诊断中的表现。方法:选用SonoVue超声造影剂,对21例经手术病理证实的乳腺癌常规超声及超声造影声像图进行回顾性分析。常规超声观察乳腺肿瘤部位,大小、形态、边界、内部回声、彩色血流分布情况。超声造影观察病灶的增强时相和方式,包括起始时间、达峰值时间、开始减退时间、完全廓清时间及病灶内部结构的增强表现。结果:常规超声显示21肿块最大直径范围1.1cm-6.0cm,实质回声团块21个,伴钙化5个。18个肿块边界清楚,3个边界尚清楚,均未见明显包膜。19个肿块发现较丰富或丰富彩色血流信号,2个显示周边少量血流信号,21个肿块测及动脉血流信号,平均Vmax 37.5cm/s(范围15.1-95.4 cm/s),RI 0.63-0.83。术前常规超声诊断符合率为85.71%(18/21)。超声造影时21个肿块平均增强起始时间(14.54±3.24)s、达峰值时间(22.64±4.15)s、开始消退时间(59.09±10.25)s、完全廓清时间(115.45±16.70)s乳腺癌造影后内部表现:16例(乳腺浸润性导管癌15例,乳腺神经内分泌癌1例)表现为不均匀增强,其中5例周围见放射状血管;3例(乳腺浸润性导管癌)表现为不完全增强;1例(乳腺浸润性筛状癌)周边不均匀增强,内部始终未见造影剂进入;1例(乳腺黏液腺癌)周边环状增强,边缘显示一穿支血管进入肿块内,走行弯曲,其余部分显示零星增强。乳腺癌造影后边界表现:18例乳腺肿瘤边界模糊,造影后肿块测值均大于常规超声大小,1例(乳腺黏液腺癌)边界清楚;2例(1例乳腺浸润性筛状癌,1例乳腺神经内分泌癌)边界尚清楚,呈分叶状。超声造影后诊断符合率为95%(20/21)。结论:实时超声造影有助于提高乳腺癌诊断的准确性。
Objective：To approach the appearance of SonoVue real-time ultrasonic contrast in the diagnosis of breast cancer.Methods：We adopted SonoVue acoustic contrast agent,and did the retrospective analysis to the routine ultrasound and the sonogram of ultrasound imaging in 21 cases of breast cancer.Results：The routine ultrasound was used to observe 21 cases of tumor,diameter were among 1.1-6.0cm,and 21 cases were essence resonance tumor,3 cases were calcification.18 tumors＇ boundary was clear,3 tumors＇ boundary was relatively clearly,and there was no obvious membrance in all of them.There was abundant or relatively abundant multicolor blood signal in 19 tumors,and there was little blood signal in 2 tumors＇ perimeter.Arterial blood signal was detected in 21 tumors,whose max was 37.5/s（range 15.1-95.4cm/s） and RI was 0.63-0.83.The diagnose accordance rate for preoperative routine ultrasound was 85.71%（18/21）.The ultrasonic contrast showed impetus time of average accentuation（14.54±3.24）s,peaking time（22.64±4.15）s,beginning decreased time（59.09±10.25）s,complete clearance time（115.45±16.70）s for 21 cases.The internal appearance of the opacification in breast cancer was that 16 cases showed even accentuation（15 cases of infitrating ductal carcinoma and 1 case of neuroendocrine carcinoma）,in five of which we could see radiate vascellum in the periphery;3 cases（infitrating ductal carcinoma） showed not complete accentuation;1 cases（invasive cribriform carcinoma） showed uneven accentuation in periphery and there was no constrast medium in it all the time;1 case（mucinous adenocarcinoma） showed ring accentuation in periphery,the borderline displayed a branch of blood vessel extending curvature into the tumor,and the other part showed odds and ends accentuation.The boundary appearance of the contrast in breast cancer was that the edge of 18 cases was unsharpness whose tumor measure value exceeded outine ultrasound after contrast;the edge of 1 case（mucinous adenocarcinoma） was distinct;the edge of 2 cases（1 invasive cribriform carcinoma and 1 neuroendocrine carcinoma） was relatively distinct,and sublobed.The diagnose accordance rate was 95%（20/21）after ultrasonic contrast.Conclusion：Real-time ultrasonic contrast can improve the accurate rate of the diagnosis of breast tumor.
出处
《现代肿瘤医学》
CAS
2011年第4期684-688,共5页
Journal of Modern Oncology
基金
陕西省卫生厅卫生科研基金项目(编号:2010D13)
