摘要
目的：探讨阴茎手术对勃起功能的影响并评估术后长期小剂量使用伐地那非对勃起功能的恢复作用。方法：选择阴茎手术患者共60例，随机分为两组：伐地那非治疗组和对照组，每组30例。治疗组术后5—7d开始服用伐地那非10mg，隔日1次，持续12周；对照组口服维生素E100mg，每日1次，持续12周。IIEF-5问卷评估术前和用药后3个月、6个月勃起功能改变。结果：治疗组术前IIEF-5评分为（14．21±3．62）分，术后3、6个月IIEF-5评分[（18．83±2．98）分，（20．13±2．98）分]较手术前提高，差异均有显著性（P均〈0．05）；而对照组患者术后3个月勃起功能下降，IIEF-5评分（13．38±2．82）分较术前（15．80±3．02）分降低，差异有显著性（P〉0．05）。治疗组术后IIEF-5评分较对照组高（P〈0．05）。结论：阴茎手术后小剂量长期服用伐地那非有助于恢复和保持阴茎的勃起功能。
Objective： To investigate the impact of penile surgery on the erectile function of the patient and to evaluate the role of small-dose vardenafil in restoring the impaired penile erection. Methods： Sixty cases of penile cavernosum surgery were equally and randomly divided into a vardenafil and a control group, the former treated 5 -7 days after surgery with 10 mg vardenafil every other day, while the latter given vitamin E at 100 mg once a day, both for 12 weeks. The penile erectile function of the patients was evaluated with the IIEF-5 questionnaire before surgery and at 3 and 6 months after vardenafil medication. Results： The mean IIEF-5 scores of the vardenafil group were 18.83 ± 2.98 and 20.13 ±2.98 at 3 and 6 months after vardenafil medication, significantly higher than 14.21 ±3.62 before surgery （ P 〉 0. 05 ）, while that of the control group was significantly decreased at 3 months as compared with the preoperative score （ 13.38 ± 2.82 versus 15.80 ±3.02, P 〈0.05）. The vardenafil group showed the highest IIEF-5 score after surgery （ P 〈 0.05 ）. Conclusion ： Long-term administration of small-dose vardenafil after penile surgery helps to restore and maintain penile erectile function.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2011年第4期322-324,共3页
National Journal of Andrology
基金
上海市"科技创新计划"基础研究重点项目(08JC1414000)~~
