摘要
AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
AIM：To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS：Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups：a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS：Absolute differences in areas under the curves were-1102.5（95%CI：-1980.3 to-224.7,P=0.0194） in the placebo group and-152.7（95%CI：-1604.2 to 641.6,P=0.8172） in the rebamipide group. Peak values of time intensity curves were-148.0（95% CI：-269.4 to-26.2,P=0.0225） in the placebo group and 28.3（95%CI：-269.0 to 325.6,P=0.8343） in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION：Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
基金
Supported by Hokkaido University Hospital
