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细胞周期素依赖蛋白激酶5(CDK5)研究进展 被引量：3

Progress of Cyclin-dependent Kinase(CDK5)
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摘要 CDK5属于细胞周期素依赖性蛋白激酶(CDK)家族成员,在多种组织中表达,可对细胞的分化和凋亡起作用,也可以通过磷酸化不同的底物发挥多种生物学作用。本文就其特性和功能进行了综述。 CDK5 is one of the members of cyclin-dependent kinase（CDK） family,which is expressed in many tissues.CDK5 can play a role in cell differentiation and apoptosis.CDK5 can also play a variety of different biological effects on the substrate by phosphorylation.In this paper,the characteristics and functions of CDK5 were overviewed.
作者 范瑞文 张俊珍 刘佳 董常生
机构地区 山西农业大学动物科技学院
出处 《畜牧兽医杂志》 2010年第6期47-49,共3页 Journal of Animal Science and Veterinary Medicine
基金 山西农业大学校内创新基金(2006001) 国家自然科学基金(30671512)
关键词 CDK5 细胞分化 细胞凋亡 磷酸化 CDK5 cell differentiation cell apoptosis phosphorylation
分类号 Q952 [生物学—动物学]
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参考文献6

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  • 2Nakano N,Nakano A,Ishidoh K,et al.CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes[J].Dermatol.2005,153(1):37-45.
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二级参考文献26

  • 1Rajgopal Y, Vemuri MC. Ethanol induced changes in cyclin-dependent kinase-5 activity and its activators,P35,P67 (Munc-18) in rat brain. Neurosci Lett, 2001, 308(3): 173-176.
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共引文献17

同被引文献28

  • 1吴旭,王保捷,张国华,官大威,汪德文,杨丽,刘长胜.大鼠脑损伤分级自由落体打击模型的建立[J].中国法医学杂志,2005,20(1):1-3. 被引量：35
  • 2李如波,贾静涛,藤谷登,木村博司.实验性脑弥漫性轴索损伤的组织病理学变化[J].中国法医学杂志,2006,21(1):1-4. 被引量：7
  • 3Connell-Crowley L, Le Gall M, Vo DJ, et al. The cyclin-dependent kinase Cdk5 controls multiple as- pects of axon patterning in vivo[J]. Curr Biol,2000, 10(10) :599-602.
  • 4Ino H, Ishizuka T, Chiba T, et al. Expression of CDK5 (PSSALRE kinase), a neural cdc2-related pro- tein kinase, in the mature and developing mouse central and peripheral nervous systems[J]. Brain Res, 1994,661 ( 1-2 ) : 196-206.
  • 5He X, Takahashi S, Suzuki H, et al. Hypomyelination phenotype caused by impaired differentiation of oligo- dendrocytes in Emxl-cre mediated Cdk5 conditional knockout mice[J]. Neurochem Res,2011,36 (7) : 1293- 1303.
  • 6Zheng YL, Li BS, Kammgo J, et cd. Cdk5 Modu- lation of mitogen-activated protein kinase signaling regulates neuronal survival[J]. Mol Biol Ce11,2007,18(2):404-413.
  • 7Dhariwala FA, Rajadhyaksha MS. An unusual mem- ber of the Cdk family: Cdk5[J]. Cell Mol Neurobiol, 2008,28 (3):351-369.
  • 8Rashidian J, Rousseaux MW, Venderova K, et al. Essential role of cytoplasmic cdk5 and Prx2 in mul- tiple ischemic injury models, in vivo[J]. J Neurosci, 2009,29 (40) :12497-12505.
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畜牧兽医杂志
2010年 第6期

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