摘要
目的探讨7种常用治疗心脑血管疾病的中药注射剂不良反应的特点和规律,为临床合理用药提供参考。方法采用回顾性研究方法,对中国医院数字图书馆CHKD期刊知识库1994～2010年报道的血栓通、三七总皂苷、参麦等7种常用中药注射剂不良反应病例进行统计分析。结果这7种常用治疗心脑血管疾病的中药注射剂所引起的不良反应在40岁以上的患者中发生率较高,多在用药过程中半小时内发生,且不良反应累及多个系统-器。临床表现复杂多样,主要表现为过敏反应,严重者可出现过敏性休克。各种中药注射剂致不良反应在性别年龄、不良反应发生时间、不良反应类型等有各自规律与特点。结论临床医务工作者应了解常用治疗心脑血管疾病的中药注射剂所致不良反应的一般规律和特点,加强其应用的监测,以减少不良反应的发生。
Objective To explore the general pattern and characteristics of adverse reaction induced by seven traditional Chinese medicine injections so as to provide some guidance for clinical rational use of drug.Methods A retrospective analysis was conducted on 607 cases of seven traditional Chinese medicine injections＇ adverse reaction reported in domestic medical journals included in CHKD database from 1994 to 2010.Results Adverse reaction of seven traditional Chinese medicine injections for cardio-cerebrovascular disease often occurred in the people at the age of over 40 years old.The onest of adverse reaction was usually within 30 minutes after injection.Adverse reaction could involve in multiple organs and systems,and clinical manifestations were various,mainly were allergic reaction.Severe allergic reaction could result in anaphylactic shock.Adverse reaction of every drug had themselves general pattern and characteristics in sex and age and type and so on.Conclusion Doctors and pharmacists should know the pattern and characteristics of adverse reaction,and the use of traditional Chinese medicine injection should be under strict monitoring to reduce the occurrence of serious adverse reaction.
出处
《中国药物警戒》
2011年第5期312-315,共4页
Chinese Journal of Pharmacovigilance
关键词
中药注射剂
不良反应
文献分析
合理用药
traditional Chinese medicine injection
adverse reaction
analysis of literature
rational use of drug
