摘要
目的观察丙泊酚和咪达唑仑复合芬太尼在ICU术后机械通气患者中的镇静效果。方法选择ICU术后机械通气患者40例。随机分为两组:B组(丙泊酚组)以0.5～2mg(/kg·h)的输注速度维持目标镇静深度(Ramsay评分2～5分);M组(咪唑安定组)以0.05～0.1mg(/kg·h)的输注速度维持同样的目标镇静深度,两组均复合芬太尼0.5μg(/kg·h)的输注速度镇痛。记录Ramsay评分、TSS评分、Prince-Henry评分,心率(HR)、无创平均动脉压(MBP)、脉氧饱和度(SpO2)、总镇静时间、停药后苏醒时间、芬太尼用量、不良事件。结果总镇静时间、芬太尼用药量、不良事件发生率两组差异无统计学意义(P>0.05)。停药后苏醒时间B组短于M组,两组差异具有统计学意义(P<0.05)。两组病人吸痰操作给药前(T1)、操作中(T2)、操作后5min(T3)的MBP、HR、SpO2组间差异无统计学意义(P>0.05),组内差异具有统计学意义(P<0.05)。结论丙泊酚和咪达唑仑复合芬太尼均能为ICU术后机械通气患者提供安全有效的镇静镇痛治疗。B组停药后苏醒时间短于M组。
Objective To study the sedation effects of propofol,midazolam and fentanyl in postoperative ICU patients with mechanical ventilation.Methods 40 postoperative ICU patients were randomly divided into group B（propofol group）and group M（midazolam group）,group B were sedated to keep target depth of sedation（Ramsay score 2～5points）with infusion speed of 0.5～2mg/（kg·h）,group M were sedated to keep same target depth of sedation with infusion speed of 0.05～ 0.1mg/（kg·h）,and the two groups were both given fentanyl with infusion speed of 0.5μg/（kg·h）.Then the Ramsay score,TSS score,Prince-Henry score,heart rate,non-traumatic mean arterial blood pressure,pulse oxygen saturation,total sedation time,recovery time after drug withdrawal,amount of fentanyl and adverse reactions of two groups were recorded.Results There were no significant differences in total sedation time,amount of fentanyl and incidence of adverse reactions between the two groups.The recovery time after drug withdrawal in group B was shorter than that in group M,and there was a significant differences（P〈0.05）.The MBP,HR,SpO2 of two groups before sputum aspiration at pre-administration（T1）,in operation（T2）and after operation at 5 min（T3） had no significant differences,but the results of intraclass had significant differences（P〈0.05）.Conclusion The propofol,midazolam and fentanyl can provide safe and effective sedation and analgesia for postoperative ICU patients with mechanical ventilation.
出处
《海南医学》
CAS
2011年第10期86-88,共3页
Hainan Medical Journal
