摘要
α2肾上腺素受体(α2-AR)激动剂可乐定,早在20世纪70年代初就已经作为强效的抗高血压药上市。其主要通过激动大脑和脊髓α2-AR产生镇静、镇痛效应,临床应用中具有减少术中麻醉药用量、增强术后镇静、镇痛及与其他镇痛药相互协同的特点。现就α2-AR结构、分型、分布和生理功能及其常用激动剂的临床应用情况和镇静镇痛作用机制的研究进展予以综述。
Back in early 1970s,clonidine,an alpha-2 adrenergic（α2-AR） receptor agonist,has been used as a listed potent anti-hypertensive.Alpha-2 adrenergic receptor produces sedative and analgesic effects mainly through the activation of brain and spinal cord alpha-2 adrenergic receptor.α2-AR receptor agonist is characteristic of reducing the dose of intraoperative anesthetic,increasing postoperative sedation and analgesia,and synergizing with other analgesics in clinical practice.This article reviews the structure,classification,distribution and physiological function and clinical application of α2-AR agonists,in addition to the research progress of sedative and analgesic mechanisms.
出处
《医学综述》
2011年第9期1386-1388,共3页
Medical Recapitulate
关键词
Α2肾上腺素受体激动剂
镇静
镇痛
Alpha-2adrenergic receptor agonist
Sedation
Analgesia
