摘要
目的对衡阳市2010年4-12月手足口病(HFMD)实验室检测结果进行分析,了解衡阳市HFMD流行特征,为今后制定或调整HFMD防治措施提供参考。方法对2010年4-12月衡阳市各县区疾病预防控制中心(CDC)及各类医疗机构送检的625例临床诊断为HFMD患者标本,应用实时荧光(Real-time)RT-PCR法检测标本中的人肠道病毒(HEV)、肠道病毒71型(EV71)和柯萨奇病毒A组16型(CVA16)特异性核酸。结果 625例HFMD患者标本中,EV71阳性率为26.08%(163/625),CVA16阳性率为8.80%(55/625),其它HEV阳性率为19.84%(124/625);95例HFMD重症病例中,EV71阳性率(67.80%,40/95)最高,并且男性阳性率(50.85%)略高于女性(27.78%),未检出CVA16型;9例HFMD重症死亡病例中,6例为EV71型,阳性率为66.67%。4-7月为HFMD高发期,3岁以下为高风险年龄组,重症病例及重症死亡病例比其它年龄组高。结论衡阳市2010年HFMD发病率较高,EV71型是引起重症及重症死亡病例的优势病毒型,应加强监测,特别是3岁以下婴幼儿的监测。
Objective To analyze the laboratory diagnosis results and epidemiological features of hand-foot-mouth disease（HFMD） in Hengyang from April to December,2010,and to provide the reference for formulating or adjusting HFMD prevention measures in future. Methods Totally 625 samples from HFMD patients were collected from county CDCs and medical institutions of Hengyang from April to December,2010.Specific nucleic acids of human enterovirus（HEV）,enterovirus 71（EV71） and coxasckievirus A group of 16 type（CVA16） were detected by real-time fluorescence RT-PCR method. Results Among the 625 samples,the positive rates of EV71,CVA16,and other HEV were 26.08%（163/625）,8.80%（55/625）,and 19.84%（124/625）,respectively.In the 95 HFMD severe cases,EV71-positive rate was the highest（67.80%,40/95）, and moreover,males＇ positive rate（50.85%） was slightly higher than that of females（27.78%）,and no CVA16 was detected.In the 9 HFMD death cases,6 were EV71,with the positive rate of 66.67%.The peak of HFMD was from April to July.The age distribution was mainly in the group under 3-year-old,moreover,severe cases and death cases in this group were more than other age groups. Conclusions The prevalence of HFMD is serious in Henegyang in 2010.EV71 is the major enterovirus causing HFMD severe cases and death cases.Surveillance should be strengthened,especially in the group under 3-year-old.
出处
《实用预防医学》
CAS
2011年第4期728-730,共3页
Practical Preventive Medicine
