摘要
目的研究血管生成素(Angs)与多发性骨髓瘤(MM)的关系并探讨其临床意义。方法用双抗体夹心酶联免疫吸附测定法检测60例MM患者不同时期的Angs血清浓度,观察其与MM临床分期、肿瘤量分级和治疗效果的关系。结果 MM患者血清中Ang-2较正常对照组明显升高;血清Ang-1含量与正常对照组差异无统计学意义。MM患者Ⅱ期的Ang-2血清水平显著低于Ⅲ期。不同肿瘤量分级的MM患者血清Ang-2含量差异有统计学意义。MM治疗有效者,血清Ang-2水平比治疗前明显降低,血清Ang-1水平与治疗前差异无统计学意义;治疗无效者,其血清Ang-1、Ang-2含量与治疗前比较差异均无统计学意义。结论 MM患者血清Ang-2水平测定对MM的发病机制研究、病情评价、疗效监测、预后预测有一定意义。
Objective To explore the relationship of angiopoietins（Angs） with multiple myeloma（MM） and its clinical significance.Methods The serum concentration of Angs in different periods was detected by double-antibody sandwich enzyme-linked immunosorbent assays technique in 60 cases of MM patients and 20 controls.The associations between the serum cytokines levels with MM stages（Ⅱ~ Ⅲ）,tumor load and the curative effect were observed,respectively.Results Pretreatment MM had significantly higher serum Ang-2 levels than controls.Serum Ang-1 levels in pretreatment MM had no significant difference compared with controls.Pretreatment serum Ang-2 levels were significantly lower in stage Ⅱ than in stage Ⅲ of MM.There weas significant difference between the different tumor load.In the patients responding to chemotherapy,Ang-2 serum levels was significantly decreased,while serum Ang-1 levels was no significant difference.In the patients who did not achieve a remission,there was no significantly change in serum Ang-1 levels and serum Ang-2 levels.Conclusion Serum levels of Ang-2 detection in MM patients is a certain extent significance to study of the pathogenesis of MM,the condition evaluation,efficacy monitoring,and outcome of prediction.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第4期431-433,共3页
Cancer Research on Prevention and Treatment
基金
河北省自然科学基金资助项目(C2008001097)
