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舒芬太尼复合地佐辛术后镇痛对二尖瓣置换患者免疫功能的影响 被引量:12

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摘要 目的 观察舒芬太尼复合地佐辛用于二尖瓣置换患者术后静脉自控镇痛的效果及其对免疫功能的影响.方法 将60例需行二尖瓣置换术患者随机分为两组,观察组应用舒芬太尼复合地佐辛术后镇痛,对照组单纯应用舒芬太尼.观察两组患者视觉模拟评分(VAS评分)及不良反应,测定其血浆IL-6、IL-10含量.结果 两组患者各时点VAS评分差异无统计学意义(P>0.05).对照组术后不良反应发生率为50%,高于观察组的16%(x2=4.66,P<0.05);两组患者血浆IL-6在术毕、术后24、48 h差异均有统计学意义,对照组均高于观察组;两组患者血浆IL-10在术后24、48 h差异均有统计学意义,对照组均低于观察组.结论 舒芬太尼复合地佐辛应用于二尖瓣置换患者术后镇痛效果明显,对免疫功能影响较小.
出处 《中国医师杂志》 CAS 2011年第3期416-418,共3页 Journal of Chinese Physician
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  • 1夏建国,彭坚,肖红,张佳,孙建斌.小剂量氯胺酮静脉自控镇痛对严重烧伤休克期患者细胞因子平衡的影响[J].中国危重病急救医学,2006,18(1):32-35. 被引量:22
  • 2[1]Brownstein M J.A brief history of opiates,opioid peptides and opioid receptors.Proc Nail Acad Sci USA,1993,90(12):5391-5393.
  • 3[2]Martin W R,Eades C G,Thompson J A,et al.The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog.J Pharmacol Exp her,1976,197(3):517-532.
  • 4[3]Gilbert P E,Martin W R.The effects of morphine-and nalorphine-like drugs in the nondependent,morphine-dependent and cyclazocine-dependent chronic spinal dog.J Pharmacol Exp Ther,1976,198(1):66-82.
  • 5[4]Dhawan B N,Cesselin F,Raghubir R,et al.Classification of opioid receptors.Pharmacol Rev,1996,48:567~592.
  • 6[6]Martin W T.The effects of morphine and nalorphine liked rugs in the nondependent and morphine-dependent chromic spinal dog.Pharmacol Exp Ther,1976,198(1):66-82.
  • 7[7]Zadina J E,Hackler L,Ge L J,et al.A potent and selective endogenous agonist for the mu-opiate receptor.Nature,1997,386(6624):499-501.
  • 8[9]Dun N J,Dun S L,Hwang L L.Nociceptin-like immunoreactivity in autonomic nuclei of the rat spinal cord.Neurosci Lett,1997,234(2-3):95-98.
  • 9[10]Kieffer B L,Gaveriaux-Ruff C.Exploring the opioid system by gene knockout.Prog Neurobiol,2002,66:285~306
  • 10[11]Parnot C,Miserey-Lenkei S,Bardin S,et al.Lessons from constitutively active mutants of Gprotein-coupled receptors.Trends Endocrinol Metab,2002,13(8):336~343

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  • 1曾居华,马恒涛,廖盈盈,李志英,陈步刚,曹芳.地佐辛联合舒芬太尼用于手术后静脉镇痛900例疗效观察[J].云南医药,2013,34(4):298-300. 被引量:4
  • 2张玲,王美芹,王仁慧,李安宁,何平.术后静脉和硬膜外镇痛的效果比较[J].安徽医药,2006,10(1):47-48. 被引量:12
  • 3杨芃,黄文起.七氟醚在成人门诊手术中的应用[J].临床麻醉学杂志,2006,22(3):239-240. 被引量:84
  • 4王云珍,王保国.酒石酸布托啡诺的研究进展[J].麻醉与监护论坛,2006,13(4):211-214. 被引量:15
  • 5庄心良,曾因明,陈伯銮.现代麻醉学[M].3版.北京:人民卫生出版社,2008:600.
  • 6Naja MZ,Zisde MF,Lonnqvist PA,et al.Nerve-stimulator guidedparavertebral blockse vs general ansesthesia for breastsurgery:a pro-spective randomized trail[J].Ew J Anamthemol,2003,20(11):897-903.
  • 7Hansen EG,Duedahl TH,Romsing J,et al.Intra-operative remifen-tanil might influence pain levels in the immediate post-operative pe-riod after major abdominal surgery[J].Acta Anaesthesiol Scand,2005,49(10):1464-1470.
  • 8Ficher BD,Dykstra LA.Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in as-says of schedule-controlled responding and thertnal nociception[J].J Pharmacol Exp Ther,2006,318(3):1300-1306.
  • 9刘俊,徐越峰.地佐辛用于瑞芬太尼静脉麻醉术后痛觉过敏的观察[J].中国医药前沿,2009,4(24):15-16.
  • 10Shin YK,Kim YD,Collea JV. The effect of propofol on isolated human pregnant uterine muscle. Anesthesiology, 1998,89 ( 1 ) : 105-109.

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