摘要
目的探讨老年糖尿病并发脑梗死患者载脂蛋白和C反应蛋白的水平变化及其临床意义。方法研究对象为老年糖尿病并发急性脑梗死患者(DACI组)47例,老年非糖尿病性急性脑梗死患者(NDACI组)45例。采用酶法测定其血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-I(ApoA-I)和载脂蛋白B(ApoB)的水平,散射免疫比浊法测定高敏C反应蛋白(hs-CRP),比较两组间各项指标的差异。结果与NDACI组相比,DACI组患者血清中TC、TG、LDL-C、ApoB水平明显升高(P<0.01),HDL、ApoA-I水平明显降低(P<0.01),hs-CRP水平明显升高(P<0.05)。结论 ApoA-I、ApoB和hs-CRP的水平与脑梗死密切相关,可作为判断糖尿病合并脑血管并发症的高危预测因子。
Objective To investigate clinical significances of apolipoprotein and C-reactive protein in elderly diabetic patients complicated by cerebral infarction.Methods 47 elderly patients with diabetic acute cerebral infarction（the DACI group） and 45 elderly patients without diabetic acute cerebral infarction（the NDACI group） were involved.Levels of total cholesterol（TC）,triglycerides（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,Apo lipoprotein A-I（ApoA-I） and Apo lipoprotein B（ApoB） were measured with the enzyme method.The level of high sensitive C-reactive protein（hs-CRP）was measured with the scatter immune turbidity method.The indexes were compared.Results Levels of TC,TG,LDL-C and ApoB in the DACI group were significantly higher than those in the NDACI group（P0.01）,while levels of HDL-C and ApoA-I were significantly lower（P0.01）.hs-CRP level in the DACI group was significantly higher than that in the NDACI group（P0.05）.Conclusion Levels of ApoA-I,ApoB and hs-CRP are closely associated with cerebral infarction,and can be considered as high-risk predictors for diabetes mellitus complicated by cerebral infarction.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第3期5-7,17,共4页
Journal of Shandong University:Health Sciences
关键词
载脂蛋白
C反应蛋白
糖尿病
脑梗死
老年
Apolipoprotein
C-reactive protein
Diabetes mellitus
Cerebral infarction
Elderly
