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NOB1基因与肿瘤 被引量：3

NOB1 gene and tumors
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摘要 NOB1基因是新发现的一个与细胞周期及转录调节有密切关系的基因。NOB1编码的蛋白质包括一个PIN(PilTamino terminus)结构域和一个ZNRD1(锌带)结构域,PIN结构域和转录相关,而ZNRD1结构域在细胞周期调节中起重要作用。研究发现,NOB1与胃癌、食管癌、卵巢癌等肿瘤的发生发展有密切关系。本文主要就NOB1基因特点及其在肿瘤发生发展中的作用作一综述。 NOB1 is a newly found gene regulating the function of the 26S proteasome,cell cycle and gene transcription.NOB1 contains a zinc ribbon domain and a PIN domain.Recent studies have indicated that the PIN domain is related to gene transcription and the zinc ribbon domain plays an important role in regulating cell cycle.It has also been found that NOB1 is closely associated with development and progression of gastric,esophageal,and ovarian cancer.The paper reviews the role of NOB1 in the development and progression of tumors.
作者 董波 邹绍武 艾开兴
机构地区 上海交通大学附属上海第六人民医院普通外科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2011年第4期432-434,共3页 Academic Journal of Second Military Medical University
关键词 NOB1基因 蛋白酶体 细胞周期蛋白 肿瘤 NOB1 gene proteasome cyclins neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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参考文献17

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第二军医大学学报
2011年 第4期

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