摘要
目的:研究模拟宫腔液成分对铜/低密度聚乙烯(Cu/LDPE)纳米复合材料宫内节育器(IUD)中Cu2+释放的影响。方法:根据模拟宫腔液的成分和浓度配制了6种浸泡溶液,用紫外分光光度计测试复合材料IUD在浸泡溶液中Cu2+的释放速率,用标准接触角仪测试复合材料与浸泡溶液的接触角,用pH计测试浸泡溶液的pH值。结果:模拟宫腔液成分可改变溶液与复合材料的接触角,以及浸泡溶液的pH值,进而对复合材料IUD的Cu2+释放速率产生较大影响。含Cl-无机正盐、葡萄糖、人血白蛋白能加速Cu2+的释放,但酸式盐的加入使Cu2+释放速率降低。结论:模拟宫腔液成分对复合材料IUD的Cu2+释放速率产生较大影响。
Objective：To study the influence of the different compositions of the simulated uterine solution on the Cu2＋ release of copper/low density polyethylene（Cu/LDPE） nanocomposite IUDs.Methods：Based on the compositions and concentrations of the simulated uterine solution,the six immersion solutions were prepared.The UV spectrophotometer was used to test the Cu2＋ release of the Cu/LDPE nanocomposite IUDs in theimmersion solutions;the contact angle of immersion solutions on the Cu/LDPE nanocomposites was obtained using the contact angle instrument;the pH value of immersion solutions was tested using the pH meter.Results：The compositions of the simulated uterine solution had significant effects on their pH value,as well as their contact angle on the Cu/LDPE nanocomposites,and the Cu2＋ release of Cu/LDPE nanocomposite IUDs was affected by the compositions of the simulated uterine solution as a result.The inorganic salts,glucose and serum albumin could accelerate the release of Cu2＋ and the acid salts could reduce the release ofCu2＋.Conclusion：The compositions of the simulated uterine solutions affect the Cu2＋ release of the Cu/LDPE nanocomposite IUDs remarkably.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2011年第4期231-235,245,共6页
Reproduction and Contraception
基金
"十一五"国家科技支撑计划:新型宫内节育器的研制
项目编号:2006BAI03B01
