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Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer 被引量：2

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer
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摘要 AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.CONCLUSION: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer. AIM： To evaluate the presence of extracapsular invasion （ECI） in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS： Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS： In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.CONCLUSION： Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.
作者 Takaaki Fujii Yuichi Tabe Reina Yajima Satoru Yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano
机构地区 Depart ment of General Surgical Science
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第15期2003-2006,共4页 世界胃肠病学杂志（英文版）
基金 Supported by Grants-in-Aid from the Japanese Ministry of Education, Culture, Sports, Science, and Technology
关键词 Extracapsular invasion Lymph node METASTASIS Colorectal cancer Risk factor Adjuvant therapy 复发间隔 大肠癌 疾病 危险因素 入侵 ECI 淋巴结 单因素分析
分类号 R735.3 [医药卫生—肿瘤]
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参考文献17

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同被引文献84

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  • 2Li-Ping Wang,Hong-Yan Wang,Rui Cao,Cong Zhu,Xiong-Zhi Wu.Proposal of a New Classification for Stage III Colorectal Cancer Based on the Number and Ratio of Metastatic Lymph Nodes[J]. World Journal of Surgery . 2013 (5)
  • 3J. Lykke,O. Roikj?r,P. Jess.The relation between lymph node status and survival in S tage I– III colon cancer: results from a prospective nationwide cohort study[J]. Colorectal Dis . 2013 (5)
  • 4Sukamal Saha,Gregory Johnston,Alpesh Korant,Mohammed Shaik,Mohammed Kanaan,Rebecca Johnston,Balvant Ganatra,Sunil Kaushal,Dilip Desai,Sreenivas Mannam.Aberrant drainage of sentinel lymph nodes in colon cancer and its impact on staging and extent of operation[J]. The American Journal of Surgery . 2013 (3)
  • 5Rebecca Siegel,Deepa Naishadham,Ahmedin Jemal.Cancer statistics, 2013[J]. CA: A Cancer Journal for Clinicians . 2013 (1)
  • 6Oddmund Nordg?rd,Satu Oltedal,Ole Gunnar Aasprong,Jon Arne S?reide,Kjetil S?reide,Kjersti Tjensvoll,Bj?rnar Gilje,Reino Heikkil?,Marianne Guriby,Ragnhild A. Lothe,Rune Smaaland,Hartwig K?rner.Prognostic Relevance of Occult Metastases Detected by Cytokeratin 20 and Mucin 2 mRNA Levels in Sentinel Lymph Nodes from Colon Cancer Patients[J]. Annals of Surgical Oncology . 2012 (12)
  • 7M. Tayyab,A. Sharma,A. W. MacDonald,J. Gunn,J. E. Hartley,J. R. T. Monson.Prognostic significance of lymph node ratio in patients undergoing abdominoperineal resection of rectum[J]. Langenbeck’s Archives of Surgery . 2012 (7)
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  • 9Edwin Zaag,Wim Bouma,Pieter Tanis,Dirk Ubbink,Willem Bemelman,Christianne Buskens.Systematic Review of Sentinel Lymph Node Mapping Procedure in Colorectal Cancer[J]. Annals of Surgical Oncology . 2012 (11)
  • 10Ulrich Güller,Andreas Zettl,Mathias Worni,Igor Langer,Daniela Cabalzar‐Wondberg,Carsten T. Viehl,Nicolas Demartines,Markus Zuber.Molecular investigation of lymph nodes in colon cancer patients using one‐step nucleic acid amplification (OSNA)[J]. Cancer . 2012 (24)

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二级引证文献15

World Journal of Gastroenterology
2011年 第15期

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