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不同年龄组妇女HPV感染流行病学研究 被引量:15

Epidemiologic study on cervical HPV infection among different age women
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摘要 目的:了解不同年龄组妇女人类乳头瘤病毒(HPV)感染状况及子宫颈癌前病变或子宫颈癌发病情况,为子宫颈癌防治提供依据。方法:整群抽样调查深圳市福田区教育系统女性职工,并进行HPV感染检测及子宫颈癌与癌前病变流行病学调查,评价不同年龄组妇女HPV感染及子宫颈癌前病变或子宫颈癌检出情况。结果:纳入研究的健康妇女2 052例,HPV阳性率12.03%,C INⅠ以上病变检出率1.71%;HPV阳性率高峰年龄在<30岁及40~44岁年龄组,阳性率分别为13.40%和14.70%;35~44岁年龄组C INⅠ以上病变检出率2.28%,显著高于其他年龄组,差异具有统计学意义(P<0.05)。结论:30岁以下年轻妇女高危型HPV阳性多为一过性感染,不推荐HPV检测作为年龄<30岁妇女的子宫颈癌前病变或子宫颈癌的筛查方案,子宫颈防治的重点人群应是35岁以上的妇女。 Objective:To investigate the distribution of human papillomavirus(HPV) infection and the cervical cancer or its precursor(cervical intraepithelial neoplsia,CIN) in different age women,providing evidence for the prevention of cervical cancer.Methods:By cluster sampling,the women who employed at the education system in Futian district of Shenzhen were selected to detect the HPV infection state and cervical cancer or cervical intraepithelial neoplasia(CIN) to evaluate the incidence of HPV infection and cervical cancer or CIN at different age.Results:Of the 2 052 cases,247 were tested HPV positive(12.03%),35 were found CIN I or greater lesion with histology.HPV infection had two peak prevalence at the age between 40 to 44(14.7%) and younger than 30(13.40%).The incidence(2.28%) of CIN I or greater lesion in the group aged between 35 to 44 were obviously higher than others and had significant difference.Conclusion:It is transient for the women aged below 30 years old to have high risk HPV infection.We don't recommend HPV test in women aged below 30 years old as a screening program for cervical cancer and its precursor.The prevention of cervical cancer should emphasize on women aged beyond 35 years old.
出处 《中国妇幼保健》 CAS 北大核心 2011年第14期2155-2157,共3页 Maternal and Child Health Care of China
基金 深圳市科技计划项目〔200404151〕 中国癌症基金会资助项目〔2004001〕
关键词 子宫颈癌 人乳头瘤病变 子宫颈上皮内瘤变 Cervical cancer HPV CIN
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  • 1Parkin DM, Pisani P, Ferlay I, et al. Global cancer statistics [J] . CA Cancer J Clin, 1999, 49 (1): 31.
  • 2李连弟,鲁凤珠,张思维,牧人,孙秀娣,皇甫小梅,孙杰,周有尚,欧阳宁慧,饶克勤,陈育德,孙爱明,薛志福,夏毅.中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J].中华肿瘤杂志,1997,19(1):3-9. 被引量:869
  • 3Elliott PM, Tattersall MH, Coppleson M, et aL Changing character of cervical cancer in young women [ J] . BMJ, 1989, 298 (6685) : 1451.
  • 4王启俊,祝伟星,邢秀梅,李玲.北京城区居民1982年~1997年癌症发病趋势[J].中国肿瘤,2001,10(9):507-509. 被引量:80
  • 5Woodman CB, Collins S, Winter H, et al. Nature history of cervical human papillomavirus infection in young women: a longitudinal cohorts study [J] . The Lancet, 2001, 357 (9271) : 1831.
  • 6Richart RM. A modifed terminology for cervical intraepithelial neoplasia [J] . Obstet Gynecol, 1990, 75 (1) : 131.
  • 7Zur Hausen H. Condylomata acuminata and human genital cancer [ J] . Cancer Res, 1976, 36 (2pt2): 794.
  • 8Belinson J, Qiao YL, Pretorius R, et al. Prevalence of cervical cancer and feasibility of screening in rural China : A pilot study for the Shanxi province cervical cancer screening study [J].Int J Gynecol Cancer, 1999, 9 (5): 411.
  • 9Franceschi S. The IARC commitment to cancer prevention: the example of papillomavirus and cervical cancer [J] . Recent Results Cancer Res, 2005, 166:277.
  • 10石菊芳,吴瑞芳,刘植华,周庆芝,李霓,乌兰娜,李晴,王倩,刘彬,李瑞珍,乔友林.深圳妇女人乳头瘤病毒的型别分布[J].中国医学科学院学报,2006,28(6):832-836. 被引量:37

二级参考文献35

  • 1刘彬,陈汶,任生达,刘新伏,马俊飞,崔剑峰,王秀荣,陈凤,乔友林.液基细胞学剩余标本筛查子宫颈病变中人乳头状瘤病毒DNA的应用[J].中华检验医学杂志,2005,28(5):495-497. 被引量:18
  • 2李洁,刘宝印,zur Hausen H,王宏,杨学志,李力,刘文,刘洪隐,陆克昭,刘旭,牛春燕,裴润芳,苏钟浦,王言贵,董继华,张桂宁,刘春杰,许吉林,林毓纯.中国妇女宫颈癌组织中人乳头瘤病毒感染及其地理分布的调查[J].中华实验和临床病毒学杂志,1996,10(1):50-55. 被引量:67
  • 3李瑞珍,石菊芳,周庆芝,吴瑞芳,李霓,乌兰娜,周艳秋,王倩,刘志红,刘彬,乔友林.应用基因芯片技术检测高危型人乳头瘤病毒在宫颈癌筛查中的评价[J].中华医学杂志,2006,86(5):307-311. 被引量:52
  • 4The International Agency for Research on Cancer.GLOBOCAN 2002 database:summary table by cancer.http://www.dep.iarc.fr.
  • 5Walboomers JM,Jacobs MV,Manos MM,et al.Human pa-pillomavirus is a necessary cause of invasive cervical cancer worldwide.J Pathol,1999,189(1):12-19.
  • 6Harper DM,Franco EL,Wheeler C,et al.Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women:a randomised controlled trial.Lancet,2004,364(9447):1757-1765.
  • 7Galloway DA.Papillomavirus vaccines in clinical trials.Lancet Infect Dis,2003,3(8):469-475.
  • 8Villa LL,Costa RL,Petta CA,et al.Prophylactic quadrivalent human papillomavirus (types 6,11,16,and 18) L1 virus-like particle vaccine in young women:a randomised dou-ble-blind placebo-controlled multicentre phase Ⅱ efficacy trial.Lancet Oncol,2005,6(5):271-278.
  • 9Cogliano V,Baan R,Straif K,et al.Carcinogenicity of human papillomaviruses.Lancet Oncol,2005,6(4):204.
  • 10Bosch FX,Manos MM,Munoz N,et al.Prevalence of human papillomavirus in cervical cancer:a worldwide perspective.International biological study on cervical cancer (IBSCC) Study Group.J Natl Cancer Inst,1995,87(11):796-802.

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