摘要
目的分析老年性慢性脑供血不足（CCCI）蒙特利尔认知评估量表（MoCA）及P300改变的特点，以期提高对CCCI认知功能受损的诊断水平。方法使用MocA对22倒住院老年CCCI患者及16例对照组进行认知功能测定。使用肌电一诱发电位仪的oddball程序检测患者及对照组的P300。结果老年CCCI组MoCA评定总分低于对照组，差异显著（18．23±1．8VS22．19±5．96，P〈0．05）对各项得分分析显示，主要表现在视空间与执行功能和记忆两项差异显著（2．18±0．66VS2．62±1．15，P〈．0．05；2．64±0．66vs3．44±1．15，P〈0．05）。老年CCCI组P300峰潜伏期较对照组明显延长（445．45±37，5）msvs（336．38±16．50）ms，P〈0．01。结论老年CCCI患者认知功能受损，主要表现在视空闽与执行功能和记忆受损较为突出，老年CCCI患者P300峰潜伏期延长反映认知功能受损。MoCA和P300是评估老年CCCI患者认知功能简单有效的方法。
Objective To analyze the characteristics of Montreal Cognitive Assessment （MoCA） scale and P300 changes in the patients with senile chronic cerebral circulation Insufficiency （CCCI） f0r improving diagnostic accuracy of cognition impairment in the patients with CCCI. Methods Cognitive function in 22 cases of inpatients with senile CCCI and 16 eases of control were evaIuated using MoCA. p300 was measured with auditory sense oddball program of myoeletricity--evoked potential apparatus. Results patients in the senile CCCI group had lower score of MoCA as compared with the patients in the control group and the difference was statistically significant （18.23±1.8 vs 22.19 ± 5.96, P 〈 0.05）. There was also striking differences between two groups in spatial disorientation and executive function and memory（2.18±0. 66 vs 2.62± 1.15, P 〈 0.05; 2.64± 0. 66 vs 3.44 d： 1.15, P 〈 0.05）. The P300 latency inthe senile CCCI group was significantly longer than that in the control group（445.45±37.51） ms vs（336.38±16.50）ms, P 〈（ 0. 01. Conclusions senile CCCI patients had cognition impairment and the impairment of spatial disorientation, executive function and memory was very obvious. Delay of P300 latency could reflect cognition impairment of senile CCCI patients. MoCA and P300 were can be used easily as effective methods to evaluate cognitive function of senile CCCI patients.
出处
《神经疾病与精神卫生》
2011年第2期158-160,共3页
Journal of Neuroscience and Mental Health
