摘要
胃癌死亡率占全球第2位.目前,化疗仍是晚期胃癌的主要治疗手段.尽管新药联合化疗在一定水平改善了患者的生存,但晚期胃癌中位生存仍不尽人意.迫切需要新的治疗手段改善患者的生存.随着胃癌分子生物学研究的不断深入,针对肿瘤细胞生长、凋亡、侵袭浸润以及血管生成等分子靶点提出的分子靶向治疗成为胃癌综合治疗的热点.本文将对近几年报道的晚期胃癌的分子靶向治疗结果进行简要综述.
Gastric cancer remains the second leading cause of cancer death worldwide.Currently,chemotherapy is the mainstay of treatment for patients with metastatic gastric cancer.Although new chemotherapeutic regimens improved the survival of patients with advanced gastric cancer,the median survival in all randomized trials remains unsatisfactory.Novel treatment options are urgently needed to improve the outcome of patients with advanced gastric cancer.Understanding the molecular pathways that characterize cell growth,apoptosis,angiogenesis and invasion has enabled us to use new approaches to treat this disease in clinical situations.The aim of this review is to summarize the most recent publications on targeted therapies for advanced gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第9期919-924,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30770993~~
关键词
胃癌
分子靶向治疗
表皮生长因子受体
血管内皮生长因子
多酪氨酸激酶抑制剂
Gastric cancer
Molecularly targeted therapy
Epidermal growth factor receptor
Vascular endothelial growth factor
Multityrosine kinase inhibitors
