摘要
目的:探讨周围型肺癌CT表现及与血清肿瘤标志物SCC-Ag浓度关系。方法:回顾性分析48例周围型肺癌CT表现及与血清肿瘤标志物SCC-Ag资料,对比分析其病理、CT表现与血清肿瘤标志物SCC-Ag关系。结果:30例腺癌血清SCC-Ag浓度为(1.04±0.75)ng/ml,11例鳞癌血清SCC-Ag浓度为(5.57±5.39)ng/ml,腺癌与鳞癌血清SCC-Ag浓度差异有统计学意义。肺癌的分化程度与血清SCC-Ag浓度相关系数r值为0.269。有空泡征或毛玻璃征的肺癌,其血清SCC-Ag浓度较无空泡征或毛玻璃征的肺癌低。肺癌有无深分叶征、胸膜凹陷征、瘤体直径≥3 cm、毛刺征、支气管气相、增强值≥20 HU、空洞、钙化或肺门、纵隔淋巴结肿大与血清SCC-Ag浓度差异无统计学意义。肺癌Ki-67抗原阳性百分率与血清SCC-Ag浓度相关系数r值为0.118。26例p53表达阳性肺癌SCC-Ag浓度(1.70±2.11)ng/ml,22例p53表达阴性肺癌SCC-Ag浓度(2.49±4.17)ng/ml。结论:肺癌的空泡征或毛玻璃征与其血清SCC-Ag浓度有一定负相关性;肺癌的分化程度、Ki-67抗原及p53表达与血清SCC-Ag浓度之间无明显相关性。
Objective：To discuss the correlation of CT features and the serum concentration of tumor marker SCC-Ag in peripheral lung cancer.Methods：The CT features and serum SCC-Ag concentration of 48 cases with peripheral lung cancer was retrospectively analyzed.Results：The serum SCC-Ag concentration of 30 cases with adenocarcinoma was（1.04±0.75）ng/ml and that of 11 cases with squamous carcinoma was（5.57±5.39）ng/ml.There was significant statislical diffe-rence between the serum SCC-Ag concentration of adenocarcinoma and that of squamous carcinoma.There was no correlation between the SCC-Ag concentration and the degree of tumor differentiation（r=-0.269）.Of the lung cancer with vacuole sign or ground-glass opacity,the serum SCC-Ag concentration was lower than that without.There was no significant statistical difference between serum SCC-Ag concentration of lung cancer with and without deep lobulation,pleural indentation,tumor diameter ≥3cm,spiculation,air-bronchiogram,increased CT value ≥20HU after contrast,cavity/calcification,or hilar/mediastinal lymphadenopathy.The correlation coefficient（r value） of positive rate of Ki-67 antigen and SCC-Ag concentration was 0.118.Of 26 patients having positive p53 expression,the serum SCC-Ag concentration was（1.70±2.11）ng/ml,whereas that was（2.49±4.17）ng/ml in 22 patients with p53 negative expression.Conclusion：There was negative correlation between serum SCC-Ag concentration and the vacuole sign or ground-glass opacity in peripheral lung cancer,yet no significant difference between the degree of tumor differentiation,expression of p53,Ki-67 antigen and serum SCC-Ag concentration was existed.
出处
《放射学实践》
北大核心
2011年第4期410-413,共4页
Radiologic Practice
基金
广州市属高校科技计划项目(61028)
广东省医学科研基金项目(A2004298)
广州医学院博士启动基金项目(0706073)
